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TG100-115
CAS No. 677297-51-7
TG100-115 ( TG100115;TG100 115 )
Catalog No. M15587 CAS No. 677297-51-7
A potent, selective PI3Kγ/δ with IC50 of 83/235 nM, respectively; shows no significant inhibitory activity against pI3Kα and β, and a broad panel of kinases (IC50>1 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 69 | In Stock |
|
| 10MG | 105 | In Stock |
|
| 25MG | 200 | In Stock |
|
| 50MG | 357 | In Stock |
|
| 100MG | 557 | In Stock |
|
| 500MG | 1152 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTG100-115
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective PI3Kγ/δ with IC50 of 83/235 nM, respectively; shows no significant inhibitory activity against pI3Kα and β, and a broad panel of kinases (IC50>1 uM).
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DescriptionA potent, selective PI3Kγ/δ with IC50 of 83/235 nM, respectively; shows no significant inhibitory activity against pI3Kα and β, and a broad panel of kinases (IC50>1 uM); potently inhibits edema and inflammation in response to multiple mediators known to participate in myocardial infarction, such as VEGF and platelet-activating factor, without effect on endothelial cell mitogenesis; provides potent cardioprotection, reduces infarct development and preserves myocardial function in animal MI models.COPD Discontinued
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SynonymsTG100115;TG100 115
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorPI3Kα;PI3Kβ;PI3Kγ;PI3Kδ
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Research AreaInflammation/Immunology
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IndicationCOPD
Chemical Information
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CAS Number677297-51-7
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Formula Weight346.34
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Molecular FormulaC18H14N6O2
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESOC1=CC=CC(C2=NC3=NC(N)=NC(N)=C3N=C2C4=CC=CC(O)=C4)=C1
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Chemical NamePhenol, 3,3'-(2,4-diamino-6,7-pteridinediyl)bis-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Doukas J, et al. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19866-71.
2. Doukas J, et al. J Pharmacol Exp Ther. 2009 Mar;328(3):758-65.
3. Kaneda MM, et al. Cancer Discov. 2016 Aug;6(8):870-85.
2. Doukas J, et al. J Pharmacol Exp Ther. 2009 Mar;328(3):758-65.
3. Kaneda MM, et al. Cancer Discov. 2016 Aug;6(8):870-85.
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