Sodium Camptothecin

Research use only, not for human use.

Sodium Camptothecin is a plant alkaloid, with antitumor activity. Sodium Camptothecin is a reversible inhibitor of RNA synthesis.

Sodium Camptothecin is a plant alkaloid, with antitumor activity. Sodium Camptothecin is a reversible inhibitor of RNA synthesis. Sodium Camptothecin is an effective inhibitor of adenovirus replication. Sodium Camptothecin inhibits DNA synthesis and causes breaks in intracellular preformed viral DNA .(In Vitro):Sodium Camptothecin (5 μM; 10 min) causes a severe inhibition of heterogeneously sedimenting nuclear RNA (HnRNA) synthesis . Sodium Camptothecin also blocks a specific step in the processing of ribosomal precursor RNA, allowing the conversion of 45S RNA to 32S RNA, but inhibiting the conversion of 32S RNA to 28S RNA .

Sodium Camptothecin (5 μM; 10 min) causes a severe inhibition of heterogeneously sedimenting nuclear RNA (HnRNA) synthesis.Sodium Camptothecin also blocks a specific step in the processing of ribosomal precursor RNA, allowing the conversion of 45S RNA to 32S RNA, but inhibiting the conversion of 32S RNA to 28S RNA .

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Cell Cycle/DNA Damage

DNA/RNA Synthesis

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25387-67-1

388.355

C20H17N2NaO5

>98% (HPLC)

In Vitro:?H2O : 50 mg/mL (128.75 mM)

[Na+].CCC(O)(C([O-])=O)c1cc2-c3nc4ccccc4cc3Cn2c(=O)c1CO

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(-20℃)

With Ice Pack

≥ 2 years