Cart
sales@molnova.com
TDZD-8
CAS No. 327036-89-5
TDZD-8( TDZD 8 | TDZD8 | GSK-3β Inhibitor I | NP 01139 )
Catalog No. M14061 CAS No. 327036-89-5
A potent, selective, non-ATP competitive GSK-3β inhibitor with IC50 of 2 uM; displays no activity against PKA, CK-2, PKC, and CDK1 (IC50>100 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 38 | In Stock |
|
| 10MG | 48 | In Stock |
|
| 25MG | 69 | In Stock |
|
| 50MG | 113 | In Stock |
|
| 100MG | 178 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameTDZD-8
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent, selective, non-ATP competitive GSK-3β inhibitor with IC50 of 2 uM; displays no activity against PKA, CK-2, PKC, and CDK1 (IC50>100 uM).
-
DescriptionA potent, selective, non-ATP competitive GSK-3β inhibitor with IC50 of 2 uM; displays no activity against PKA, CK-2, PKC, and CDK1 (IC50>100 uM); reduces the colonic inflammation induced by TNBS in vivo, also prevents 6-OHDA-induced neuronal cell death.
-
In Vitro——
-
In Vivo——
-
SynonymsTDZD 8 | TDZD8 | GSK-3β Inhibitor I | NP 01139
-
PathwayPI3K/Akt/mTOR signaling
-
TargetGSK-3
-
RecptorGSK-3β
-
Research AreaNeurological Disease
-
Indication——
Chemical Information
-
CAS Number327036-89-5
-
Formula Weight222.2636
-
Molecular FormulaC10H10N2O2S
-
Purity>98% (HPLC)
-
Solubility10 mM in DMSO
-
SMILESO=C(N1CC2=CC=CC=C2)N(C)SC1=O
-
Chemical Name1,2,4-Thiadiazolidine-3,5-dione, 2-methyl-4-(phenylmethyl)-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Martinez A, et al. J Med Chem. 2002 Mar 14;45(6):1292-9.
2. Whittle BJ, et al. Br J Pharmacol. 2006 Mar;147(5):575-82.
3. Dugo L, et al. Crit Care Med. 2005 Sep;33(9):1903-12.
molnova catalog
related products
-
IM-12
IM-12 is a novel potent GSK-3β inhibitor with IC50 of 53 nM, significantly increases the β-catenin level and activates canonical Wnt signalling.
-
AZD1080
AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor, inhibits human GSK3α and GSK3β with Ki of 6.9 nM and 31 nM, respectively.
-
GSK-3 Inhibitor 5
GSK-3 Inhibitor 5 (4-Cyanophenacyl bromide) is a ketone derivative that is used as an intermediate in pharmaceuticals and organic synthesis, and inhibits glycogen synthase kinase 3 (GSK-3).
