TDZD-8( TDZD 8 | TDZD8 | GSK-3β Inhibitor I | NP 01139 )

Catalog No. M14061 CAS No. 327036-89-5

A potent, selective, non-ATP competitive GSK-3β inhibitor with IC50 of 2 uM; displays no activity against PKA, CK-2, PKC, and CDK1 (IC50>100 uM).

Purity : >98% (HPLC)

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Biological Information

Product Name

TDZD-8
Note

Research use only, not for human use.
Brief Description

A potent, selective, non-ATP competitive GSK-3β inhibitor with IC50 of 2 uM; displays no activity against PKA, CK-2, PKC, and CDK1 (IC50>100 uM).
Description

A potent, selective, non-ATP competitive GSK-3β inhibitor with IC50 of 2 uM; displays no activity against PKA, CK-2, PKC, and CDK1 (IC50>100 uM); reduces the colonic inflammation induced by TNBS in vivo, also prevents 6-OHDA-induced neuronal cell death.
In Vitro

——
In Vivo

——
Synonyms

TDZD 8 | TDZD8 | GSK-3β Inhibitor I | NP 01139
Pathway

PI3K/Akt/mTOR signaling
Target

GSK-3
Recptor

GSK-3β
Research Area

Neurological Disease
Indication

——

Chemical Information

CAS Number

327036-89-5
Formula Weight

222.2636
Molecular Formula

C10H10N2O2S
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

O=C(N1CC2=CC=CC=C2)N(C)SC1=O
Chemical Name

1,2,4-Thiadiazolidine-3,5-dione, 2-methyl-4-(phenylmethyl)-

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Martinez A, et al. J Med Chem. 2002 Mar 14;45(6):1292-9. 2. Whittle BJ, et al. Br J Pharmacol. 2006 Mar;147(5):575-82. 3. Dugo L, et al. Crit Care Med. 2005 Sep;33(9):1903-12.

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