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BIO
CAS No. 667463-62-9
BIO( 6BIO | 6-BIO | GSK 3 IX | GSK 3 Inhibitor IX | MLS 2052 | MLS2052 )
Catalog No. M15548 CAS No. 667463-62-9
A cell-permeable derivative of 6-bromoindirubin that displays selective inhibition of GSK-3 with IC50 of 5 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 45 | In Stock |
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| 5MG | 68 | In Stock |
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| 10MG | 93 | In Stock |
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| 25MG | 216 | In Stock |
|
| 50MG | 390 | In Stock |
|
| 100MG | 578 | In Stock |
|
| 500MG | 1233 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBIO
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NoteResearch use only, not for human use.
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Brief DescriptionA cell-permeable derivative of 6-bromoindirubin that displays selective inhibition of GSK-3 with IC50 of 5 nM.
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DescriptionA cell-permeable derivative of 6-bromoindirubin that displays selective inhibition of GSK-3 with IC50 of 5 nM; also inhibit CDK1/Cyclin B and CDK5/p25 (IC50, 320 nM and 83 nM); maintains the undifferentiated phenotype in HESCs and MESCs, sustains the expression of Oct-3/4, Rex-1 and Nanog; promotes proliferation in mammalian cardiomyocytes.
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In Vitro——
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In Vivo——
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Synonyms6BIO | 6-BIO | GSK 3 IX | GSK 3 Inhibitor IX | MLS 2052 | MLS2052
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PathwayPI3K/Akt/mTOR signaling
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TargetGSK-3
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RecptorCDK1/CyclinB|CDK2/CyclinA|CDK5/p35|GSK-3|Tyk2
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Research AreaCardiovascular Disease
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Indication——
Chemical Information
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CAS Number667463-62-9
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Formula Weight356.1735
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Molecular FormulaC16H10BrN3O2
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 23 mg/mL
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SMILESO=C(/C1=C2NC3=C(C\2=N/O)C=CC=C3)NC4=C1C=CC(Br)=C4
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Chemical Name2H-Indol-2-one, 6-bromo-3-[(3E)-1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-, (3Z)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Meijer L, et al. Chem Biol. 2003 Dec;10(12):1255-66.
2. Tseng AS, et al. Chem Biol. 2006 Sep;13(9):957-63.
3. Sato N, et al. Nat Med. 2004 Jan;10(1):55-63.
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