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TCV-309
CAS No. 131311-25-6
TCV-309( TCV 309 | TCV309 )
Catalog No. M11257 CAS No. 131311-25-6
A highly potent and selective platelet activating factor (PAF) antagonist; inhibits PAF-induced aggregation of rabbit and human platelets with IC50s of 33 nM and 55 nM respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameTCV-309
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NoteResearch use only, not for human use.
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Brief DescriptionA highly potent and selective platelet activating factor (PAF) antagonist; inhibits PAF-induced aggregation of rabbit and human platelets with IC50s of 33 nM and 55 nM respectively.
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DescriptionA highly potent and selective platelet activating factor (PAF) antagonist; inhibits PAF-induced aggregation of rabbit and human platelets with IC50s of 33 nM and 55 nM respectively; potently protects mice from death induced by PAF and due to anaphylactic shock with ED50 of 2.1 and 2.6 ug/kg (i.v.), respectively; also reverses PAF-induced hypotension and endotoxin-induced hypotension in rats.Coagulation Disorder Phase 2 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsTCV 309 | TCV309
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PathwayGPCR/G Protein
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TargetPlatelet-activating Factor Receptor
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RecptorPlatelet-activating Factor Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number131311-25-6
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Formula Weight656.534
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Molecular FormulaC30H34BrN5O7
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Purity>98% (HPLC)
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Solubility——
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SMILESCCC[N+]1=CC(C(N(CCC(NCCOC(N2CC3=C(C=CC=C3)CC2)=O)=O)C4=CC=CC=C4)=O)=CC(Br)=C1.[O-][N+]([O-])=O
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Chemical Name3-bromo-5-((3-oxo-3-((2-((1,2,3,4-tetrahydroisoquinoline-2-carbonyl)oxy)ethyl)amino)propyl)(phenyl)carbamoyl)-1-propylpyridin-1-ium nitrate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Terashita Z, et al. J Pharmacol Exp Ther. 1992 Feb;260(2):748-55.
2. Motoyama N, et al. Eur J Pain. 2013 Sep;17(8):1156-67.
3. Kuipers B, et al. J Immunol. 1994 Mar 1;152(5):2438-46.
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