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TBOPP

CAS No. 1996629-79-8

TBOPP ( —— )

Catalog No. M22123 CAS No. 1996629-79-8

TBOPP is a selective DOCK1 inhibitor (IC50 : 8.4 μM), with anti-tumor activity for broader types of tumors.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    TBOPP
  • Note
    Research use only, not for human use.
  • Brief Description
    TBOPP is a selective DOCK1 inhibitor (IC50 : 8.4 μM), with anti-tumor activity for broader types of tumors.
  • Description
    TBOPP is a selective DOCK1 inhibitor (IC50 : 8.4 μM), with anti-tumor activity for broader types of tumors. TBOPP as a selective inhibitor of DOCK1.?TBOPP dampened DOCK1-mediated invasion, macropinocytosis, and survival under the condition of glutamine deprivation without impairing the biological functions of the closely related DOCK2 and DOCK5 proteins.TBOPP treatment suppressed cancer metastasis and growth in vivo in mice.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    DOCK1;DOCK1 DHR-2 domain
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1996629-79-8
  • Formula Weight
    490.49
  • Molecular Formula
    C24H21F3N2O4S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:120 mg/mL (244.65 mM; Need ultrasonic)
  • SMILES
    FC(F)(F)c1cccc(c1)-c1ccc(cc1)C(=O)Cn1cc(ccc1=O)S(=O)(=O)N1CCCC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Tajiri H, et al. Targeting Ras-Driven Cancer Cell Survival and Invasion through Selective Inhibition of DOCKCell Rep. 2017 May 2;19(5):969-980.
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