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TB5
CAS No. 948841-07-4
TB5( TB5, TB 5, TB-5 )
Catalog No. M17687 CAS No. 948841-07-4
TB5 is a potent, selective and reversible inhibitor of hMAO-B.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 37 | In Stock |
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| 10MG | 59 | In Stock |
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| 25MG | 109 | In Stock |
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| 50MG | 177 | In Stock |
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| 100MG | 284 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameTB5
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NoteResearch use only, not for human use.
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Brief DescriptionTB5 is a potent, selective and reversible inhibitor of hMAO-B.
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DescriptionTB5 is a MAO-B inhibitor. TB5 showed the inhibitory activity and selectivity toward hMAO-B, with Ki and SI values of 0.11±0.01?μm and 13.18, respectively. TB5 was found to be nontoxic at 5 and 25?μm, with 95.75 and 84.59?% viability among cells, respectively.
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In VitroTB5 and TB8 interacts with the catalytic site of hMAO-B and hMAO-A with a competitive mode of inhibition. TB5 shows the best inhibitory activity and higher selectivity toward hMAO-B, with Ki and SI values of 0.11±0.01μM and 13.18, respectively. hMAO-B inhibition by compound TB5 and hMAO-A inhibition by compound TB8 are completely reversed after 24 h of dialysis. Cytotoxicity studies show TB5 is nontoxic at 5 and 25 μM, resulting in cell viabilities of 95.75% and 84.59 %, respectively.
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In VivoCompounds are dissolved in DMSO (5 mg/mL) and diluted with PBS/EtOH (70:30).Kinetic analyses are carried out for TB5 and TB8. A set of Lineweaver–Burk plots are constructed in the absence and presence of various concentrations of compounds TB5 and TC8. The set consists of five graphs, each constructed by measuring MAO-B and MAO-A catalytic rates at different substrate concentrations (0.1-1 μM). The first Lineweaver–Burk plot is constructed in the absence of inhibitor, while the remaining four graphs are constructed in the presence of different concentrations of TB5 and TB8.
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SynonymsTB5, TB 5, TB-5
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PathwayOthers
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TargetOther Targets
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RecptorhMAO-B
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number948841-07-4
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Formula Weight336.25
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Molecular FormulaC15H14BrNOS
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 10 mg/mL (29.74 mM)
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SMILESCN(C)c1ccc(cc1)/C=C/C(=O)c1ccc(s1)Br
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Chemical Name(2E)-1-(5-bromothiophen-2-yl)-3-[4-(dimethylamino)phenyl]prop-2-en-1-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Isocarlinoside
Isocarlinoside, L-malic acid, trans-aconitic acid, (+)-isocitric acid , 5-O-caffeoylquinic acid, 4-O-caffeoylquinic acid, 2"-O-rhamnosylisoorientin, and 7-O-(2"-O-glucuronosyl)glucuronosyltricin showed high antifeeding activity against brown planthopper only when they were combined.
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MAGE-A3 195-203
This peptide MAGE-3-encoded HLA-A24 epitope is a high MHC binder.The identification of this MAGE-3/HLA-A24 peptide may as a result effectiveially offer the opportunities to design peptide-based immunotherapeutic approaches that might prove to be potent in treating patients with MAGE-3-positive malignant tumors.
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3-Phenylbutyric acid
3-Phenylbutyric acid isolates Rhodococcus rhodochrous PB1 from compost soil and is metabolized by initial oxidation of the benzene ring and by initial oxidation of the side chain.
