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TAP-311
CAS No. 1149362-88-8
TAP-311( TAP311 )
Catalog No. M10527 CAS No. 1149362-88-8
TAP-311 is a novel potent and selective CETP inhibitor with plasma IC50 of 62 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameTAP-311
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NoteResearch use only, not for human use.
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Brief DescriptionTAP-311 is a novel potent and selective CETP inhibitor with plasma IC50 of 62 nM.
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DescriptionTAP-311 is a novel potent and selective CETP inhibitor with plasma IC50 of 62 nM; displays >170-fold selectivity over CYPs, and has excellent pharmacokinetics in rats and robust efficacy in hamsters; shows substantially reduced lipophilicity with only modest distribution into adipose tissue, and retains potency in hypertriglyceridemic plasma in vitro and in vivo; does not increase blood pressure or plasma aldosterone levels in vivo, in contrast to torcetrapib.Dyslipidemia Phase 1 Clinical.
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In Vitro——
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In Vivo——
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SynonymsTAP311
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PathwayMetabolic Enzyme/Protease
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TargetCETP
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RecptorCETP
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Research AreaCardiovascular Disease
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IndicationDyslipidemia
Chemical Information
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CAS Number1149362-88-8
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Formula Weight710.72
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Molecular FormulaC34H40F6N6O4
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Purity>98% (HPLC)
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Solubility——
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SMILESCN1N=CC(C(C=N2)=CN=C2N(C3CC(CC)N(C(OC4CCC(C(O)=O)CC4)=O)C(CC)C3)CC5=CC(C(F)(F)F)=CC(C(F)(F)F)=C5)=C1
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Chemical Name4-((4-((3,5-bis(trifluoromethyl)benzyl)(5-(1-methyl-1H-pyrazol-4-yl)pyrimidin-2-yl)amino)-2,6-diethylpiperidine-1-carbonyl)oxy)cyclohexane-1-carboxylic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yamada K, et al. J Med Chem. 2017 Oct 26;60(20):8466-8481.
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