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T863
CAS No. 701232-20-4
T863 ( T863, T 863, T-863 )
Catalog No. M19018 CAS No. 701232-20-4
T-863(DGAT-1 inhibitor) is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells.
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 41 | In Stock |
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| 5MG | 67 | In Stock |
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| 10MG | 97 | In Stock |
|
| 25MG | 219 | In Stock |
|
| 50MG | 365 | In Stock |
|
| 100MG | 531 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameT863
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NoteResearch use only, not for human use.
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Brief DescriptionT-863(DGAT-1 inhibitor) is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells.
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DescriptionT-863(DGAT-1 inhibitor) is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells. IC50 value: Target: DGAT1 T863 causes weight loss, reduction in serum and liver triglycerides, and improved insulin sensitivity in obese mice.
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SynonymsT863, T 863, T-863
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PathwayCell Cycle/DNA Damage
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TargetDNA/RNA Synthesis
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RecptorDGAT1
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Research AreaMetabolic Disease
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Indication——
Chemical Information
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CAS Number701232-20-4
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Formula Weight394.47
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Molecular FormulaC22H26N4O3
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Purity98%
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SolubilityDMSO : ≥ 50 mg/mL; 126.75 mM
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SMILESO=C(O)C[C@@H]1CC[C@H](CC1)c2ccc(cc2)C4=Nc3c(ncnc3N)OC4(C)C
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Chemical Nametrans-4-[4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexaneacetic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Cao J, et al. Targeting Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) with small molecule inhibitors for the treatment of metabolic diseases. J Biol Chem. 2011 Dec 2;286(48):41838-51.
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