2,4-Dichlorophenoxyacetic acid

Research use only, not for human use.

2,4-Dichlorophenoxyacetic acid is a synthetic auxin used as a plant growth regulator and also used as a supplement in plant cell culture media.

2,4-Dichlorophenoxyacetic acid is a synthetic auxin used as a plant growth regulator and also used as a supplement in plant cell culture media. It is an active ingredient in herbicides used to disrupts the actin cytoskeleton for the control of root elongation and cell production.

Cell Viability Assay Cell Line:A549, W138 Concentration:25, 50, 75, 100, 150, 200 μM Incubation Time:72 h Result:Inhibited cell viability in a dose-dependent manner.Cell Cycle Analysis Cell Line:A549 Concentration:50, 100, 150 μM Incubation Time:72 h Result:The G0/G1 population decreased to about 57%, 43% and 31%, respectively.Apoptosis Analysis Cell Line:A549, W138 Concentration:100, 150 μM Incubation Time:72 h Result:The early apoptotic population increased to 44% in A549 cells and 57% in WI38 cells, and the late apoptotic population increased to 18% in A549 cells and 10% in WI38 cells.Western Blot Analysis Cell Line:A549, W138 Concentration:100, 150 μM Incubation Time:72 h Result:Up-regulated p53 and Bax proteins, down-regulated Bcl-2 and procaspase 3.

Animal Model:Adult Wistar male rats Dosage:100 or 200 mg/kg Administration:i.g.Result:Decreased the testis, seminal vesicles and prostate relative weight.Decreased the number of spermatozoa and sperm motility.Increased the level of FSH and LH.

2,4-D acid | Chloroxone | Chloroxone | Macondray | Hedonal

Cell Cycle/DNA Damage

DNA/RNA Synthesis

DNA synthesis

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94-75-7

221.03

C8H6Cl2O3

>98% (HPLC)

DMSO:100 mg/mL?(452.41 mM;?Need ultrasonic)

C1=CC(=C(C=C1Cl)Cl)OCC(=O)O

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(-20℃)

With Ice Pack

≥ 2 years