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T2AA

CAS No. 1380782-27-3

T2AA ( 4-[4-[(2S)-2-amino-3-hydroxypropyl]-2,6-diiodophenoxy]phenol; ZINC95605533 )

Catalog No. M28054 CAS No. 1380782-27-3

T2AA is an inhibitor of proliferating cell nuclear antigen (PCNA) with IC50 of 1 μM for PCNA/PIP-box peptide interaction.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    T2AA
  • Note
    Research use only, not for human use.
  • Brief Description
    T2AA is an inhibitor of proliferating cell nuclear antigen (PCNA) with IC50 of 1 μM for PCNA/PIP-box peptide interaction.
  • Description
    T2AA is an inhibitor of proliferating cell nuclear antigen (PCNA) with IC50 of 1 μM for PCNA/PIP-box peptide interaction. T2AA suppresses cancer cell growth and causes DNA replication stress by stalling DNA replication forks and inhibiting PCNA interaction with DNA polymerase δ.
  • Synonyms
    4-[4-[(2S)-2-amino-3-hydroxypropyl]-2,6-diiodophenoxy]phenol; ZINC95605533
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA/RNA Synthesis
  • Recptor
    Antifungal;Coagulation factor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1380782-27-3
  • Formula Weight
    511.1
  • Molecular Formula
    C15H15I2NO3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O(C1=C(I)C=C(C[C@@H](CO)N)C=C1I)C2=CC=C(O)C=C2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Kumar N, et al. Isolation and antifungal properties of cyclo(D-Tyr-L-Leu) diketopiperazine isolated from Bacillus sp. associated with rhabditid entomopathogenic nematode. Natural Product Research 2013, 27(23):2168-217
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