T-448 free base ( T448;T 448 )

Catalog No. M12283 CAS No. 1597426-52-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

T-448 free base
Note

Research use only, not for human use.
Brief Description

T-448 free base (T448) is a specific inhibitor of LSD1 enzyme activity.
Description

T-448 free base (T448) is a specific inhibitor of LSD1 enzyme activity, enhances H3K4 methylation in primary cultured rat neurons but has little impact on LSD1-GFI1B complex in human TF-1a erythroblasts; increases brain H3K4 methylation and partially restored learning function in mice with NMDA receptor hypofunction, shows unique therapeutic approaches for central nervous system disorders associated with epigenetic dysregulation.
Synonyms

T448;T 448
Pathway

Chromatin/Epigenetic
Target

Histone Demethylase
Recptor

Histone Demethylase
Research Area

——
Indication

——

CAS Number

1597426-52-2
Formula Weight

328.43
Molecular Formula

C17H20N4OS
Purity

>98% (HPLC)
Solubility

——
SMILES

CC1=NN=C(S1)NC(=O)C2=CC=CC(=C2)C3CC3NC4CCC4
Chemical Name

3-((1S,2R)-2-(cyclobutylamino)cyclopropyl)-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzamide

1. Matsuda S, et al. Neuropsychopharmacology. 2018 Dec 22. doi: 10.1038/s41386-018-0300-9.

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