Cart
sales@molnova.com
KDM5-C70
CAS No. 1596348-32-1
KDM5-C70 ( KDM5 inhibitor C70 )
Catalog No. M12280 CAS No. 1596348-32-1
KDM5-C70 is the cell-permeable derivative of KDM5-C49, potent, selective and cell permeable KDM5 inhibitor with IC50 of 0.3, 0.3 and 0.58 uM for KDM5A, B and C, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 33 | Get Quote |
|
| 5MG | 50 | Get Quote |
|
| 10MG | 73 | Get Quote |
|
| 25MG | 129 | Get Quote |
|
| 50MG | 232 | Get Quote |
|
| 100MG | 464 | Get Quote |
|
| 200MG | 663 | Get Quote |
|
| 500MG | 1017 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameKDM5-C70
-
NoteResearch use only, not for human use.
-
Brief DescriptionKDM5-C70 is the cell-permeable derivative of KDM5-C49, potent, selective and cell permeable KDM5 inhibitor with IC50 of 0.3, 0.3 and 0.58 uM for KDM5A, B and C, respectively.
-
DescriptionKDM5-C70 is the cell-permeable derivative of KDM5-C49, potent, selective and cell permeable KDM5 inhibitor with IC50 of 0.3, 0.3 and 0.58 uM for KDM5A, B and C, respectively; significantly increases global levels of H3K4me3, while having little impact on H3K4me2/me1, or modifications regulated by other histone lysine demethylases, such as H3K27me3 (substrate for the KDM6 family) and H3K9me3/H3K36me3 (substrates for the KDM4 family).
-
SynonymsKDM5 inhibitor C70
-
PathwayChromatin/Epigenetic
-
TargetHistone Demethylase
-
RecptorHistone Demethylase
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1596348-32-1
-
Formula Weight336.43
-
Molecular FormulaC17H28N4O3
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=C(OCC)C1=CC=NC(CNCC(N(CCN(C)C)CC)=O)=C1
-
Chemical NameEthyl 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinate
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Johansson C, et. Nat Chem Biol. 2016 Jul;12(7):539-45.
2. Horton JR, et al. Cell Chem Biol. 2016 Jul 21;23(7):769-81.
2. Horton JR, et al. Cell Chem Biol. 2016 Jul 21;23(7):769-81.
molnova catalog
related products
-
T-448
T-448 (T448) is a specific inhibitor of LSD1 enzyme activity, enhances H3K4 methylation in primary cultured rat neurons but has little impact on LSD1-GFI1B complex in human TF-1a erythroblasts.
-
SGC-iMLLT
SGC-iMLLT is a potent and selective MLLT1/3-histone interactions inhibitor(IC50 = 0.26 μM),and is a first-in-class chemical probe displaying cellular target engagement of MLLT1(Kd = 0.129?μM) and MLLT3(Kd = 0.077?μM).
-
TC-E 5003
TC-E 5003 is a selective inhibitor of PRMT1 with IC50 of 1.5 μM.
