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Sulfuretin
CAS No. 120-05-8
Sulfuretin( —— )
Catalog No. M23371 CAS No. 120-05-8
Sulfuretin is a potent anti-oxidant, has protective effect against t-BHP-induced oxidative damage in human liver-derived HepG2 cells is attributable to its ability to scavenge ROS and up-regulate the activity of HO-1 through the Nrf2/ARE and JNK/ERK signaling pathways.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 203 | In Stock |
|
| 10MG | 334 | In Stock |
|
| 25MG | 563 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameSulfuretin
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NoteResearch use only, not for human use.
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Brief DescriptionSulfuretin is a potent anti-oxidant, has protective effect against t-BHP-induced oxidative damage in human liver-derived HepG2 cells is attributable to its ability to scavenge ROS and up-regulate the activity of HO-1 through the Nrf2/ARE and JNK/ERK signaling pathways.
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DescriptionSulfuretin is a potent anti-oxidant, has protective effect against t-BHP-induced oxidative damage in human liver-derived HepG2 cells is attributable to its ability to scavenge ROS and up-regulate the activity of HO-1 through the Nrf2/ARE and JNK/ERK signaling pathways.
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In VitroSulfuretin is one of the main flavonoids produced by Rhus verniciflua. Sulfuretin efficiently inhibits the infiltration of inflammatory cells and attenuates allergic airway inflammation.
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In VivoSulfuretin inhibits the inflammatory responses by suppressing the NF-κB pathway in type 1 diabetes models. Sulfuretin (40 μg/kg; single intraperitoneal injection 2 h after the last OVA challenge) suppresses ovalbumin (OVA)-induced chemotaxis and airway inflammation. Animal Model:Pathogen-free male BALB/c mice (7-8 weeks old)Dosage:40 μg/kg Administration:A single intraperitoneal injection was administered 2 h after the last OVA challengeResult:Suppressed OVA-induced chemotaxis and airway inflammation.
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Synonyms——
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PathwayAutophagy
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TargetAutophagy
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Recptor(HO)-1
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Research Area——
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Indication——
Chemical Information
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CAS Number120-05-8
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Formula Weight270.24
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Molecular FormulaC15H10O5
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Purity>98% (HPLC)
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SolubilityDMSO:10 mM
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SMILESC1=CC(=C(C=C1/C=C\2/C(=O)C3=C(O2)C=C(C=C3)O)O)O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.The cytoprotective effect of sulfuretin against tert-butyl hydroperoxide-induced hepatotoxicity through Nrf2/ARE and JNK/ERK MAPK-mediated heme oxygenase-1 expression.Int J Mol Sci. 2014 May 19;15(5):8863-77.
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