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Euxanthone
CAS No. 529-61-3
Euxanthone( —— )
Catalog No. M35175 CAS No. 529-61-3
Euxanthone (1,7-Dihydroxyxanthone), an xanthone derivative extracted from the roots of Polygala tenuifolia Willd, has antitumour, neuroprotective and vasorelaxant activities, and attenuates Aβ1-42-induced oxidative stress and apoptosis by inducing autophagy.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 296 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameEuxanthone
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NoteResearch use only, not for human use.
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Brief DescriptionEuxanthone (1,7-Dihydroxyxanthone), an xanthone derivative extracted from the roots of Polygala tenuifolia Willd, has antitumour, neuroprotective and vasorelaxant activities, and attenuates Aβ1-42-induced oxidative stress and apoptosis by inducing autophagy.
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DescriptionEuxanthone, a xanthone derivative, attenuates Aβ1-42-induced oxidative stress and apoptosis by triggering autophagy. Euxanthone exhibits anti-neoplastic and neuroprotective activities.
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In VitroCell Migration Assay Cell Line:Osteosarcoma (OS) cells Concentration:10 μM, 20 μM Incubation Time:24 h Result:Inhibited cell migration at 24 hr. Western Blot Analysis Cell Line:Osteosarcoma (OS) cells,Concentration:10 μM, 20 μM Incubation Time:24 h Result:Repressed both the mRNA and protein level of COX-2 in OS cells in a dose-dependent fashion.
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In VivoAnimal Model:Forty male ICR mice (20 g) induced cerebral ischemia and reperfusion Dosage:30 mg/kg, 60 mg/kg Administration:p.o.;once a day; for 7 days Result:Markedly attenuated BCCAO triggered mitochondrial stress and related breakdown.
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Synonyms——
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PathwayAutophagy
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TargetAutophagy
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RecptorAutophagy
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Research Area——
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Indication——
Chemical Information
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CAS Number529-61-3
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Formula Weight228.2
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Molecular FormulaC13H8O4
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C1C2=CC(O)=CC=C2OC=3C=CC=C(O)C13
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Xiaodong Chen, et al. Euxanthone Impairs the Metastatic Potential of Osteosarcoma by Reducing COX-2 Expression. Anat Rec (Hoboken). 2019 Aug;302(8):1399-1408.?
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