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Sorafenib-d3

CAS No. 1130115-44-4

Sorafenib-d3( Sorafenib (D3) | Bay 43-9006 (D3) )

Catalog No. M26821 CAS No. 1130115-44-4

Sorafenib-d3 is a deuterium-labeled Sorafenib which is a multikinase inhibitor(IC50s: 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Sorafenib-d3
  • Note
    Research use only, not for human use.
  • Brief Description
    Sorafenib-d3 is a deuterium-labeled Sorafenib which is a multikinase inhibitor(IC50s: 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively).
  • Description
    Sorafenib-d3 is a deuterium-labeled Sorafenib which is a multikinase inhibitor(IC50s: 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively).
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Sorafenib (D3) | Bay 43-9006 (D3)
  • Pathway
    MAPK/ERK Signaling
  • Target
    Raf
  • Recptor
    TGFβ
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1130115-44-4
  • Formula Weight
    467.84
  • Molecular Formula
    C21H16ClF3N4O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (213.75 mM)
  • SMILES
    O(C=1C=C(C(NC([2H])([2H])[2H])=O)N=CC1)C2=CC=C(NC(NC3=CC(C(F)(F)F)=C(Cl)C=C3)=O)C=C2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Bowen C, et al. Mitochondrial-related effects of pentabromophenol, tetrabromobisphenol A, and triphenyl phosphate on murine BV-2 microglia cells. Chemosphere. 2020 Sep;255:126919.
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