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Exarafenib

CAS No. 2639957-39-2

Exarafenib( —— )

Catalog No. M35731 CAS No. 2639957-39-2

Exarafenib (RAF/KIN_2787) is a potent, orally available pan-RAF inhibitor with antitumor activity that acts by inhibiting downstream MAPK pathway signaling. It is used in cancer research.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Exarafenib
  • Note
    Research use only, not for human use.
  • Brief Description
    Exarafenib (RAF/KIN_2787) is a potent, orally available pan-RAF inhibitor with antitumor activity that acts by inhibiting downstream MAPK pathway signaling. It is used in cancer research.
  • Description
    Exarafenib (RAF/KIN_2787) is an orally-available, selective pan-RAF inhibitor. Exarafenib is effective in RAF-dependent cancers, including all classes of BRAF alterations. Exarafenib suppresses MAPK signaling in RAF-dependent melanoma cell lines. Exarafenib has anticancer activity.
  • In Vitro
    Cell Viability AssayCell Line:Melanoma cell (A375 BRAFV600E, HMVII BRAFG469V; NRASQ61K, WM3629 BRAFD594G; NRASG12D, SKMEL2 NRASQ61R) Concentration:1-10000 nM Incubation Time:24 h Result:Inhibited RAF-dependent melanoma cell line growth.
  • In Vivo
    Animal Model:BALB/c nude mice xenograft models of BRAF and NRAS-mutant melanoma Dosage:3, 5, 10, 20, 30 mg/kg Administration:Orally; twice daily (BID); 29 days Result:Was effective against BRAFmut & NRASmut human melanoma xenografts in vivo.
  • Synonyms
    ——
  • Pathway
    MAPK/ERK Signaling
  • Target
    Raf
  • Recptor
    Raf | p38 MAPK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2639957-39-2
  • Formula Weight
    521.58
  • Molecular Formula
    C26H34F3N5O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (191.73 mM; Ultrasonic )
  • SMILES
    C[C@H](CO)Nc1cc(cc(n1)N1CCOCC1)-c1cc(NC(=O)N2CC[C@@H](CC(F)(F)F)C2)ccc1C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Miller N, et, al. Antitumor activity of KIN-2787, a next-generation pan-RAF inhibitor, in combination with MEK inhibition in preclinical models of human NRAS mutant melanoma.2022 Jun 2;40(16): e15099.
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