Sobetirome ( QRX-431;IACS-010759 )

Catalog No. M20074 CAS No. 211110-63-3

Sobetirome is a selective agonist of thyroid hormone receptor β (TRβ) and binds selectively to TRβ-1 (EC50: 0.16 μM).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Sobetirome
Note

Research use only not for human use.
Brief Description

Sobetirome is a selective agonist of thyroid hormone receptor β (TRβ) and binds selectively to TRβ-1 (EC50: 0.16 μM).
Description

Sobetirome is a selective agonist of thyroid hormone receptor β (TRβ) and binds selectively to TRβ-1 (EC50: 0.16 μM).
Synonyms

QRX-431;IACS-010759
Pathway

Endocrinology/Hormones
Target

THR
Recptor

TRβ
Research Area

Others
Indication

Adrenoleucodystrophy

Chemical Information

CAS Number

211110-63-3
Formula Weight

328.4
Molecular Formula

C20H24O4
Purity

>98% (HPLC)
Solubility

DMSO: 30 mg/mL (91.4 mM);Ethanol: 30 mg/mL
SMILES

CC(C)c1cc(Cc2c(C)cc(OCC(O)=O)cc2C)ccc1O
Chemical Name

2-(4-(4-hydroxy-3-isopropylbenzyl)-35-dimethylphenoxy)acetic acid

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Gierach I et al. Bacterial biosensors for screening isoform-selective ligands for human thyroid receptors α-1 and β-1. FEBS Open Bio. 2012 Aug 15;2:247-53.

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