Sobetirome

CAS No. 211110-63-3

Sobetirome( QRX-431 | IACS-010759 )

Catalog No. M20074 CAS No. 211110-63-3

Sobetirome is a selective agonist of thyroid hormone receptor β (TRβ) and binds selectively to TRβ-1 (EC50: 0.16 μM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Sobetirome
  • Note
    Research use only, not for human use.
  • Brief Description
    Sobetirome is a selective agonist of thyroid hormone receptor β (TRβ) and binds selectively to TRβ-1 (EC50: 0.16 μM).
  • Description
    Sobetirome is a selective agonist of thyroid hormone receptor β (TRβ) and binds selectively to TRβ-1 (EC50: 0.16 μM).(In Vivo):Sobetirome (GC-1) is a thyroid hormone receptor β (TRβ)- and liver uptake-selective agonist. Sobetirome (48 nmol/kg) reduces high-density lipoprotein (HDL) cholesterol and very low-density lipoprotein (VLDL) triglyceride levels in euthyroid Mice. Sobetirome reduces HDL cholesterol and triglyceride Levels in hypercholesterolemic mice. Sobetirome increases hepatic HDL receptors and stimulates bile acid synthesis in hypercholesterolemic mice. Treatment with 10× Sobetirome (GC-1) results in a gain of fat mass of only 21% (1.7 g), and treatment with 20× Sobetirome (GC-1) induces a decrease in fat mass of 20%.
  • In Vitro
    ——
  • In Vivo
    Sobetirome (GC-1) is a thyroid hormone receptor β (TRβ)- and liver uptake-selective agonist. Sobetirome (48 nmol/kg) reduces high-density lipoprotein (HDL) cholesterol and very low-density lipoprotein (VLDL) triglyceride levels in euthyroid Mice. Sobetirome reduces HDL cholesterol and triglyceride Levels in hypercholesterolemic mice. Sobetirome increases hepatic HDL receptors and stimulates bile acid synthesis in hypercholesterolemic mice. Treatment with 10× Sobetirome (GC-1) results in a gain of fat mass of only 21% (1.7 g), and treatment with 20× Sobetirome (GC-1) induces a decrease in fat mass of 20% (1.3 g).
  • Synonyms
    QRX-431 | IACS-010759
  • Pathway
    Endocrinology/Hormones
  • Target
    THR
  • Recptor
    TRβ
  • Research Area
    Others
  • Indication
    Adrenoleucodystrophy

Chemical Information

  • CAS Number
    211110-63-3
  • Formula Weight
    328.4
  • Molecular Formula
    C20H24O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 30 mg/mL (91.4 mM);Ethanol: 30 mg/mL
  • SMILES
    CC(C)c1cc(Cc2c(C)cc(OCC(O)=O)cc2C)ccc1O
  • Chemical Name
    2-(4-(4-hydroxy-3-isopropylbenzyl)-35-dimethylphenoxy)acetic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Gierach I et al. Bacterial biosensors for screening isoform-selective ligands for human thyroid receptors α-1 and β-1. FEBS Open Bio. 2012 Aug 15;2:247-53.
molnova catalog
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