
Sobetirome
CAS No. 211110-63-3
Sobetirome( QRX-431 | IACS-010759 )
Catalog No. M20074 CAS No. 211110-63-3
Sobetirome is a selective agonist of thyroid hormone receptor β (TRβ) and binds selectively to TRβ-1 (EC50: 0.16 μM).
Purity : >98% (HPLC)






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Biological Information
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Product NameSobetirome
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NoteResearch use only, not for human use.
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Brief DescriptionSobetirome is a selective agonist of thyroid hormone receptor β (TRβ) and binds selectively to TRβ-1 (EC50: 0.16 μM).
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DescriptionSobetirome is a selective agonist of thyroid hormone receptor β (TRβ) and binds selectively to TRβ-1 (EC50: 0.16 μM).(In Vivo):Sobetirome (GC-1) is a thyroid hormone receptor β (TRβ)- and liver uptake-selective agonist. Sobetirome (48 nmol/kg) reduces high-density lipoprotein (HDL) cholesterol and very low-density lipoprotein (VLDL) triglyceride levels in euthyroid Mice. Sobetirome reduces HDL cholesterol and triglyceride Levels in hypercholesterolemic mice. Sobetirome increases hepatic HDL receptors and stimulates bile acid synthesis in hypercholesterolemic mice. Treatment with 10× Sobetirome (GC-1) results in a gain of fat mass of only 21% (1.7 g), and treatment with 20× Sobetirome (GC-1) induces a decrease in fat mass of 20%.
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In Vitro——
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In VivoSobetirome (GC-1) is a thyroid hormone receptor β (TRβ)- and liver uptake-selective agonist. Sobetirome (48 nmol/kg) reduces high-density lipoprotein (HDL) cholesterol and very low-density lipoprotein (VLDL) triglyceride levels in euthyroid Mice. Sobetirome reduces HDL cholesterol and triglyceride Levels in hypercholesterolemic mice. Sobetirome increases hepatic HDL receptors and stimulates bile acid synthesis in hypercholesterolemic mice. Treatment with 10× Sobetirome (GC-1) results in a gain of fat mass of only 21% (1.7 g), and treatment with 20× Sobetirome (GC-1) induces a decrease in fat mass of 20% (1.3 g).
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SynonymsQRX-431 | IACS-010759
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PathwayEndocrinology/Hormones
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TargetTHR
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RecptorTRβ
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Research AreaOthers
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IndicationAdrenoleucodystrophy
Chemical Information
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CAS Number211110-63-3
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Formula Weight328.4
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Molecular FormulaC20H24O4
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Purity>98% (HPLC)
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SolubilityDMSO: 30 mg/mL (91.4 mM);Ethanol: 30 mg/mL
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SMILESCC(C)c1cc(Cc2c(C)cc(OCC(O)=O)cc2C)ccc1O
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Chemical Name2-(4-(4-hydroxy-3-isopropylbenzyl)-35-dimethylphenoxy)acetic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Gierach I et al. Bacterial biosensors for screening isoform-selective ligands for human thyroid receptors α-1 and β-1. FEBS Open Bio. 2012 Aug 15;2:247-53.
molnova catalog



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