
Sibiriline
CAS No. 1346526-26-8
Sibiriline( Sibiriline )
Catalog No. M11395 CAS No. 1346526-26-8
A specific competitive RIPK1 inhibitor with IC50 of 1.03 uM, 100-fold less potent for RIPK3.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 873 | Get Quote |
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50MG | 1782 | Get Quote |
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100MG | 2250 | Get Quote |
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200MG | Get Quote | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameSibiriline
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NoteResearch use only, not for human use.
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Brief DescriptionA specific competitive RIPK1 inhibitor with IC50 of 1.03 uM, 100-fold less potent for RIPK3.
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DescriptionA specific competitive RIPK1 inhibitor with IC50 of 1.03 uM, 100-fold less potent for RIPK3; inhibits both TNF-induced RIPK1-dependent necroptosis and RIPK1-dependent apoptosis in FADD-deficient Jurkat cells (EC50=1.2 uM); selectively inhibits necroptotic cell death induced by various death ligands in human or mouse cells while not protecting from caspase-dependent apoptosis; protects mice from concanavalin A-induced hepatitis.
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In Vitro——
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In Vivo——
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SynonymsSibiriline
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PathwayApoptosis
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TargetRIP kinase
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RecptorRIP kinase
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Research Area——
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Indication——
Chemical Information
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CAS Number1346526-26-8
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Formula Weight210.236
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Molecular FormulaC13H10N2O
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Purity>98% (HPLC)
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Solubility——
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SMILESOC1=CC=C(C2=CC3=CC=CN=C3N2)C=C1
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Chemical Name4-(1H-Pyrrolo[2,3-b]pyridin-2-yl)phenol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Le Cann F, et al. FEBS J. 2017 Jul 17. doi: 10.1111/febs.14176.
molnova catalog



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