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Sibiriline

CAS No. 1346526-26-8

Sibiriline( Sibiriline )

Catalog No. M11395 CAS No. 1346526-26-8

A specific competitive RIPK1 inhibitor with IC50 of 1.03 uM, 100-fold less potent for RIPK3.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Sibiriline
  • Note
    Research use only, not for human use.
  • Brief Description
    A specific competitive RIPK1 inhibitor with IC50 of 1.03 uM, 100-fold less potent for RIPK3.
  • Description
    A specific competitive RIPK1 inhibitor with IC50 of 1.03 uM, 100-fold less potent for RIPK3; inhibits both TNF-induced RIPK1-dependent necroptosis and RIPK1-dependent apoptosis in FADD-deficient Jurkat cells (EC50=1.2 uM); selectively inhibits necroptotic cell death induced by various death ligands in human or mouse cells while not protecting from caspase-dependent apoptosis; protects mice from concanavalin A-induced hepatitis.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Sibiriline
  • Pathway
    Apoptosis
  • Target
    RIP kinase
  • Recptor
    RIP kinase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1346526-26-8
  • Formula Weight
    210.236
  • Molecular Formula
    C13H10N2O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    OC1=CC=C(C2=CC3=CC=CN=C3N2)C=C1
  • Chemical Name
    4-(1H-Pyrrolo[2,3-b]pyridin-2-yl)phenol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Le Cann F, et al. FEBS J. 2017 Jul 17. doi: 10.1111/febs.14176.
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