Senicapoc
CAS No. 289656-45-7
Senicapoc ( ICA-17043 )
Catalog No. M13889 CAS No. 289656-45-7
A potent, selective Gardos channel blocker that blocks Ca(2+)-induced rubidium flux from human RBCs (IC50=11 nM) and inhibits RBC dehydration (IC50=10-50 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 49 | In Stock |
|
10MG | 78 | In Stock |
|
25MG | 122 | In Stock |
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50MG | 159 | In Stock |
|
100MG | 213 | In Stock |
|
200MG | 318 | In Stock |
|
500MG | Get Quote | In Stock |
|
1G | Get Quote | In Stock |
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Biological Information
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Product NameSenicapoc
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective Gardos channel blocker that blocks Ca(2+)-induced rubidium flux from human RBCs (IC50=11 nM) and inhibits RBC dehydration (IC50=10-50 nM).
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DescriptionA potent, selective Gardos channel blocker that blocks Ca(2+)-induced rubidium flux from human RBCs (IC50=11 nM) and inhibits RBC dehydration (IC50=10-50 nM); shows greater potency and selectivity than Clotrimazole; increases RBC K(+) content and hematocrit (Hct), decreases corpuscular hemoglobin concentration (MCHC) in a transgenic mouse model of sickle cell disease (SAD); orally active.Other Indication Phase 3 Discontinued
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SynonymsICA-17043
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PathwayCell Cycle/DNA Damage
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TargetPotassium Channel
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RecptorGardoschannel
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Research AreaOther Indications
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IndicationOther Disease
Chemical Information
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CAS Number289656-45-7
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Formula Weight323.34
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Molecular FormulaC20H15F2NO
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESC1=CC=C(C=C1)C(C2=CC=C(C=C2)F)(C3=CC=C(C=C3)F)C(=O)N
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Chemical NameBenzeneacetamide, 4-fluoro-.alpha.-(4-fluorophenyl)-.alpha.-phenyl-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Stocker JW, et al. Blood. 2003 Mar 15;101(6):2412-8.
2. Ataga KI, et al. Blood. 2008 Apr 15;111(8):3991-7.
3. Minniti CP, et al. Br J Haematol. 2011 Dec;155(5):634-6.
2. Ataga KI, et al. Blood. 2008 Apr 15;111(8):3991-7.
3. Minniti CP, et al. Br J Haematol. 2011 Dec;155(5):634-6.
molnova catalog
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