Senegenin( —— )

Catalog No. M18304 CAS No. 2469-34-3

Senegenin is a natural product from Polygala tenuifolia used in Chinese medicine with antioxidative and anti-inflammatory activity.

Purity : >98% (HPLC)

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Biological Information

Product Name

Senegenin
Note

Research use only, not for human use.
Brief Description

Senegenin is a natural product from Polygala tenuifolia used in Chinese medicine with antioxidative and anti-inflammatory activity.
Description

Senegenin is a natural product from Polygala tenuifolia used in Chinese medicine with antioxidative and anti-inflammatory activity.
In Vitro

——
In Vivo

Tenuigenin (2, 4, 8 mg/kg) significantly attenuates S.aureus-induced lung histopathological changes. Tenuigenin also inhibits lung wet/dry (W/D) ratio, and inflammatory cytokines TNF-α and IL-1β production in Male BALB/c mice.
Synonyms

——
Pathway

MAPK/ERK Signaling
Target

p38 MAPK
Recptor

Caspase-3
Research Area

——
Indication

——

Chemical Information

CAS Number

2469-34-3
Formula Weight

537.1
Molecular Formula

C30H45ClO6
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (186.17 mM)
SMILES

C1[C@@H]([C@@H]([C@]([C@@H]2CC[C@]3(C4=C([C@H]5[C@@](CC4)(CCC(C5)(C)C)C(=O)O)[C@H](C[C@@H]3[C@@]12C)CCl)C)(C(=O)O)C)O)O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Li X, Zhao Y, Liu P,et al.Senegenin Inhibits Hypoxia/Reoxygenation-Induced Neuronal Apoptosis by Upregulating RhoGDIα.Mol Neurobiol. 2015 Dec;52(3):1561-71.

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