
Scopolin
CAS No. 531-44-2
Scopolin( Scopolin | Murrayin | Scopoloside )
Catalog No. M18746 CAS No. 531-44-2
Scopolin can reduce the clinical symptoms of rat AIA by inhibiting inflammation and angiogenesis, and this compound may be a potent agent for angiogenesis related diseases and can serve as a structural base for screening more potent synthetic analogs.
Purity : >98% (HPLC)






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Biological Information
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Product NameScopolin
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NoteResearch use only, not for human use.
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Brief DescriptionScopolin can reduce the clinical symptoms of rat AIA by inhibiting inflammation and angiogenesis, and this compound may be a potent agent for angiogenesis related diseases and can serve as a structural base for screening more potent synthetic analogs.
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DescriptionScopolin formation is increased by the enhanced activity of PAL. Scopolin can reduce the clinical symptoms of rat AIA by inhibiting inflammation and angiogenesis, and this compound may be a potent agent for angiogenesis related diseases and can serve as a structural base for screening more potent synthetic analogs.
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In Vitro——
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In VivoAnimal Model:HFD-fed C57BL/6?N miceDosage:0.02% (w/w) in HFD diet (equivalent to 20?mg/kg body weight)Administration:Supplemented in diet, 8 weeks Result:Reversed the HFD-induced hepatic TG, cholesterol, and fatty acid accumulation by 35%, 49%, and 35%, respectively.Reversed the HFD-induced decrease in plasma adiponectin levels by 76%, and reduced the increased plasma MCP-1, TNFα, and IL-6 levels.Restored HFD-induced downregulation of SIRT1 activity.Animal Model:Adjuvant-induced arthritis (AIA) rats Dosage:50, 100 mg/kg Administration:i.p.Result:Inhibited inoculated and non-inoculated paw swelling and articular index scores.Reduced new blood vessels, and reduced IL-6, VEGF and FGF-2 expressions in rat synovial tissues.
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SynonymsScopolin | Murrayin | Scopoloside
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PathwayApoptosis
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TargetNF-κB
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RecptorOthers
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number531-44-2
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Formula Weight354.31
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Molecular FormulaC16H18O9
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (282.24 mM)
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SMILESCOc1c(O[C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)cc2oc(=O)ccc2c1
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Chemical Name6-methoxy-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-2H-chromen-2-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference



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