Chrysotoxine

Research use only, not for human use.

Chrysotoxine inhibits 6-hydroxydopamine induced apoptosis in SH-SY5Y cells via NF-κB modulation and mitochondria protection.

Chrysotoxine inhibits 6-hydroxydopamine induced apoptosis in SH-SY5Y cells via NF-κB modulation and mitochondria protection.

Western Blot Analysis Cell Line:460, H23 cells Concentration:0-20 μM Incubation Time:Overnight Result:Significant decreased the p-Src and p-Akt expression in a dose-dependent manner instead of Src and Akt.Significantly reduced the down-stream stem cell transcription factor Sox2 as the decline of p-Src in H460 and H23 cells.Cell Viability Assay Cell Line:460, H23 cells Concentration:0, 1, 5, 10, 20 and 50 μM Incubation Time:24 h Result:Significantly reduced cell viability and increased H460 and H23 cells cell apoptosis at 50 μM with IC50s of 127.34 and 145.47 μM, respectively.Showed no cytotoxic effect on non-tumor cell lines at all tested concentrations.Cell Differentiation Assay Cell Line:460, H23 cells Concentration:5-20 μM Incubation Time:72 h Result:Decreased approximately 30, 60, 90 and 95% of the H460 CSC spheroid size at day 7 with treated 1, 5,10 and 20 μM Chrysotoxine, respectively.Decreased approximately 40, 60, 80 and 92% of the H23 CSC spheroid size at day 7 with treated 1, 5,10 and 20 μM Chrysotoxine, respectively.

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4-[2-(3,4-Dimethoxyphenyl)ethyl]-2,6-dimethoxyphenol | Phenol, 4-[2-(3,4-dimethoxyphenyl)ethyl]-2,6-dimethoxy-

Apoptosis

NF-κB

NF-κB

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156951-82-5

318.36

C18H22O5

>98% (HPLC)

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COc(ccc(CCc(cc1OC)cc(OC)c1O)c1)c1OC

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(-20℃)

With Ice Pack

≥ 2 years