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Salubrinal
CAS No. 405060-95-9
Salubrinal( Salubrinal )
Catalog No. M14390 CAS No. 405060-95-9
Salubrinal is a selective inhibitor of eukaryotic translation initiation factor 2 subunit α (eIF2α) dephosphorylation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 32 | In Stock |
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| 5MG | 50 | In Stock |
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| 10MG | 77 | In Stock |
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| 25MG | 149 | In Stock |
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| 50MG | 259 | In Stock |
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| 100MG | 441 | In Stock |
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| 500MG | 981 | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameSalubrinal
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NoteResearch use only, not for human use.
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Brief DescriptionSalubrinal is a selective inhibitor of eukaryotic translation initiation factor 2 subunit α (eIF2α) dephosphorylation.
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DescriptionSalubrinal is a selective inhibitor of eukaryotic translation initiation factor 2 subunit α (eIF2α) dephosphorylation.
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In VitroSalubrinal, a recently identified PP1 inhibitor capable to protect against endoplasmic reticulum (ER) stress in various model systems, strongly synergized with proteasome inhibitors to augment apoptotic death of different leukemic cell lines. Salubrinal preferentially seems to target the PP1/GADD34 complex, Salubrinal is of interest to examine whether the effect of Salubrinal could also be recapitulated by another inhibitor of this phosphatase. For this purpose cantharidin, wis selected, which is less toxic than okadaic acid, but which also blocks PP1 (IC50=1.7 μM) activities.
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In VivoSalubrinal is a synthetic chemical that inhibits de-phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2α). Salubrinal significantly suppresses inflammation of the paws of CAIA mice. For instance, the clinical scores are 1.94±1.7 (placebo) and 0.31±0.6 (Salubrinal) on day 6; and 4.63±3.4 (placebo) and 1.09±1.6 (Salubrinal) on day 12. Consistent with the clinical scores, the thickening of the paws is also reduced in the Salubrinal-treated group. Furthermore, Salubrinal reduces the histological scores from 1.47±1.10 (N=16; placebo) to 0.59±0.64 (N=16; Salubrinal) (p=0.01).
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SynonymsSalubrinal
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PathwayApoptosis
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TargetPERK
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RecptoreIF-2α
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number405060-95-9
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Formula Weight479.81
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Molecular FormulaC21H17Cl3N4OS
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Purity>98% (HPLC)
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SolubilityEthanol: 2 mg/mL (4.16 mM); DMSO: 96 mg/mL (200.07 mM)
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SMILESO=C(NC(NC(NC1=C2N=CC=CC2=CC=C1)=S)C(Cl)(Cl)Cl)/C=C/C3=CC=CC=C3
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Chemical Name(2E)-3-phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Isochamaejasmine
Isochamaejasmine is a biflavonoid isolated from S. chamaejasme L. with inhibition of NF-κB activation. Isochamaejasmine induces apoptosis in leukemia cells by inhibiting the activity of Bcl-2 family proteins and can be used in anti-cancer studies.
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δ-Tocotrienol
δ-Tocotrienol is a potential angiogenic inhibitor. δ-Tocotrienol is also a nontoxic activator of mir-34a which can inhibit nonsmall cell lung cancer cells (NSCLC) cell proliferation, induce apoptosis and inhibit invasion, and thus offering a potential starting point for the design of novel anticancer agents.
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Vincristine
Vincristine binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine can be used as a microtubule-destabilizing agent for research on the treatment of hematologic cancers.
