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Salirasib

CAS No. 162520-00-5

Salirasib ( Salirasib; Farnesylthiosalicylic acid; S-Farnesylthiosalicylic acid; FTS )

Catalog No. M18095 CAS No. 162520-00-5

Salirasib(Ki=2.6 μM), an effective competitive prenylated protein methyltransferase (PPMTase) inhibitor, inhibits Ras methylation with potential antineoplastic activity.

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
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25MG 87 In Stock
50MG 146 In Stock
100MG 210 In Stock
200MG 345 In Stock
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Biological Information

  • Product Name
    Salirasib
  • Note
    Research use only, not for human use.
  • Brief Description
    Salirasib(Ki=2.6 μM), an effective competitive prenylated protein methyltransferase (PPMTase) inhibitor, inhibits Ras methylation with potential antineoplastic activity.
  • Description
    Salirasib is a salicylic acid derivative with potential antineoplastic activity. Salirasib dislodges all Ras isoforms from their membrane-anchoring sites, thereby preventing activation of RAS signaling cascades that mediated cell proliferation, differentiation, and senescence. RAS signaling is believed to be abnormally activated in one-third of human cancers, including cancers of the pancreas, colon, lung and breast.
  • Synonyms
    Salirasib; Farnesylthiosalicylic acid; S-Farnesylthiosalicylic acid; FTS
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    PPMTase
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    162520-00-5
  • Formula Weight
    358.54
  • Molecular Formula
    C22H30O2S
  • Purity
    98%
  • Solubility
    DMSO : ≥ 50 mg/mL 139.45 mM; H2O : < 0.1 mg/mL
  • SMILES
    C(=O)(c1c(SC/C=C(\C)/CC/C=C(\C)/CCC=C(C)C)cccc1)O
  • Chemical Name
    2-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)benzoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Marciano D, et al. J Med Chem. 1995, 38(8), 1267-1272.
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