Salirasib ( Salirasib; Farnesylthiosalicylic acid; S-Farnesylthiosalicylic acid; FTS )

Catalog No. M18095 CAS No. 162520-00-5

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Product Name

Salirasib
Note

Research use only, not for human use.
Brief Description

Salirasib(Ki=2.6 μM), an effective competitive prenylated protein methyltransferase (PPMTase) inhibitor, inhibits Ras methylation with potential antineoplastic activity.
Description

Salirasib is a salicylic acid derivative with potential antineoplastic activity. Salirasib dislodges all Ras isoforms from their membrane-anchoring sites, thereby preventing activation of RAS signaling cascades that mediated cell proliferation, differentiation, and senescence. RAS signaling is believed to be abnormally activated in one-third of human cancers, including cancers of the pancreas, colon, lung and breast.
Synonyms

Salirasib; Farnesylthiosalicylic acid; S-Farnesylthiosalicylic acid; FTS
Pathway

Others
Target

Other Targets
Recptor

PPMTase
Research Area

Cancer
Indication

——

CAS Number

162520-00-5
Formula Weight

358.54
Molecular Formula

C22H30O2S
Purity

98%
Solubility

DMSO : ≥ 50 mg/mL 139.45 mM; H2O : < 0.1 mg/mL
SMILES

C(=O)(c1c(SC/C=C(\C)/CC/C=C(\C)/CCC=C(C)C)cccc1)O
Chemical Name

2-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)benzoic acid

1. Marciano D, et al. J Med Chem. 1995, 38(8), 1267-1272.

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