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Salermide

CAS No. 1105698-15-4

Salermide ( Salermide )

Catalog No. M10403 CAS No. 1105698-15-4

A potent Sirtuin inhibitor with IC50 of 76 and 45 uM for SIRT1 and SIRT2, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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25MG 132 In Stock
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100MG 411 In Stock
500MG 888 In Stock
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Biological Information

  • Product Name
    Salermide
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent Sirtuin inhibitor with IC50 of 76 and 45 uM for SIRT1 and SIRT2, respectively.
  • Description
    A potent Sirtuin inhibitor with IC50 of 76 and 45 uM for SIRT1 and SIRT2, respectively; prompts tumour-specific cell death in a wide range of human cancer cell lines (MCF cells at 50 uM), causes cell cycle arrest at G(1), results in the in vivo acetylation of the SIRT1/2 target p53, but not EX527.
  • Synonyms
    Salermide
  • Pathway
    Chromatin/Epigenetic
  • Target
    Sirtuin
  • Recptor
    SIRT1;SIRT2
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1105698-15-4
  • Formula Weight
    394.47
  • Molecular Formula
    C26H22N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(NC1=CC=CC(/N=C/C2=C3C=CC=CC3=CC=C2O)=C1)C(C)C4=CC=CC=C4
  • Chemical Name
    Benzeneacetamide, N-[3-[[(2-hydroxy-1-naphthalenyl)methylene]amino]phenyl]-α-methyl-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lara E, et al. Oncogene. 2009 Feb 12;28(6):781-91.
2. Peck B, et al. Mol Cancer Ther. 2010 Apr;9(4):844-55.
3. Rotili D, et al. J Med Chem. 2012 Dec 27;55(24):10937-47.
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