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Salermide
CAS No. 1105698-15-4
Salermide ( Salermide )
Catalog No. M10403 CAS No. 1105698-15-4
A potent Sirtuin inhibitor with IC50 of 76 and 45 uM for SIRT1 and SIRT2, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 42 | In Stock |
|
| 10MG | 60 | In Stock |
|
| 25MG | 132 | In Stock |
|
| 50MG | 231 | In Stock |
|
| 100MG | 411 | In Stock |
|
| 500MG | 888 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSalermide
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NoteResearch use only, not for human use.
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Brief DescriptionA potent Sirtuin inhibitor with IC50 of 76 and 45 uM for SIRT1 and SIRT2, respectively.
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DescriptionA potent Sirtuin inhibitor with IC50 of 76 and 45 uM for SIRT1 and SIRT2, respectively; prompts tumour-specific cell death in a wide range of human cancer cell lines (MCF cells at 50 uM), causes cell cycle arrest at G(1), results in the in vivo acetylation of the SIRT1/2 target p53, but not EX527.
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SynonymsSalermide
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PathwayChromatin/Epigenetic
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TargetSirtuin
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RecptorSIRT1;SIRT2
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1105698-15-4
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Formula Weight394.47
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Molecular FormulaC26H22N2O2
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(NC1=CC=CC(/N=C/C2=C3C=CC=CC3=CC=C2O)=C1)C(C)C4=CC=CC=C4
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Chemical NameBenzeneacetamide, N-[3-[[(2-hydroxy-1-naphthalenyl)methylene]amino]phenyl]-α-methyl-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lara E, et al. Oncogene. 2009 Feb 12;28(6):781-91.
2. Peck B, et al. Mol Cancer Ther. 2010 Apr;9(4):844-55.
3. Rotili D, et al. J Med Chem. 2012 Dec 27;55(24):10937-47.
2. Peck B, et al. Mol Cancer Ther. 2010 Apr;9(4):844-55.
3. Rotili D, et al. J Med Chem. 2012 Dec 27;55(24):10937-47.
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