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Home - Products - JAK/STAT Signaling - STAT - STA-21

STA-21

CAS No. 28882-53-3

STA-21 ( NSC 628869;Ochromycinone )

Catalog No. M13885 CAS No. 28882-53-3

A small-molecule inhibitor of STAT3; inhibits Stat3 DNA binding activity, Stat3 dimerization, and Stat3-dependent luciferase activity (20-30 uM).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    STA-21
  • Note
    Research use only, not for human use.
  • Brief Description
    A small-molecule inhibitor of STAT3; inhibits Stat3 DNA binding activity, Stat3 dimerization, and Stat3-dependent luciferase activity (20-30 uM).
  • Description
    A small-molecule inhibitor of STAT3; inhibits Stat3 DNA binding activity, Stat3 dimerization, and Stat3-dependent luciferase activity (20-30 uM); reduces the survival of breast carcinoma cells with constitutive Stat3 signaling; inhibits cell viability and growth and induces apoptosis through caspases 3, 8 and 9 pathways in human sarcoma cell lines.
  • Synonyms
    NSC 628869;Ochromycinone
  • Pathway
    JAK/STAT Signaling
  • Target
    STAT
  • Recptor
    STAT
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    28882-53-3
  • Formula Weight
    306.30
  • Molecular Formula
    C19H14O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC1CC2=C(C(=O)C1)C3=C(C=C2)C(=O)C4=C(C3=O)C=CC=C4O
  • Chemical Name
    (3S)-3,4-dihydro-8-hydroxy-3-methyl-benz[a]anthracene-1,7,12(2H)-trione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Song H, et al. Proc Natl Acad Sci U S A. 2005 Mar 29;102(13):4700-5.
2. Chen CL, et al. BMC Cancer. 2007 Jun 28;7:111.
3. Fuh B, et al. Br J Cancer. 2009 Jan 13;100(1):106-12.
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