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SSR125543

CAS No. 752253-39-7

SSR125543( Crinecerfont | SSR-125543 )

Catalog No. M15862 CAS No. 752253-39-7

SSR125543 (Crinecerfont, SSR-125543) is a potent, nonpeptide, orally active corticotropin-releasing factor (CRF) receptor CRF1 antagonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 593 Get Quote
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Biological Information

  • Product Name
    SSR125543
  • Note
    Research use only, not for human use.
  • Brief Description
    SSR125543 (Crinecerfont, SSR-125543) is a potent, nonpeptide, orally active corticotropin-releasing factor (CRF) receptor CRF1 antagonist.
  • Description
    SSR125543 (Crinecerfont, SSR-125543) is a potent, nonpeptide, orally active corticotropin-releasing factor (CRF) receptor CRF1 antagonist, shows anxiolytic- and antidepressant-like activities in vivo. Depression Phase 2 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Crinecerfont | SSR-125543
  • Pathway
    GPCR/G Protein
  • Target
    CRF Receptor
  • Recptor
    CRF Receptor
  • Research Area
    Neurological Disease
  • Indication
    Depression

Chemical Information

  • CAS Number
    752253-39-7
  • Formula Weight
    483.042
  • Molecular Formula
    C27H28ClFN2OS
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC1=C(C=C(C=C1)C(CC2CC2)N(CC#C)C3=NC(=C(S3)C)C4=C(C=C(C(=C4)C)OC)Cl)F
  • Chemical Name
    4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-(prop-2-yn-1-yl)-1,3-thiazol-2-amine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Louis C, et al. Neuropsychopharmacology. 2006 Oct;31(10):2180-7. 2. Overstreet DH, et al. Eur J Pharmacol. 2004 Aug 16;497(1):49-53. 3. Claustre Y, et al. Neuroscience. 2006 Sep 1;141(3):1481-8. 4. Urani A, et al. Pharmacol Biochem Behav. 2011 May;98(3):425-31.
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    SSR125543 (Crinecerfont, SSR-125543) is a potent, nonpeptide, orally active corticotropin-releasing factor (CRF) receptor CRF1 antagonist.

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