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SR59230A
CAS No. 174689-39-5
SR59230A ( —— )
Catalog No. M21725 CAS No. 174689-39-5
SR59230A is a potent, selective, and blood-brain barrier penetrating β3-adrenergic receptor antagonist with IC50s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 63 | In Stock |
|
| 5MG | 98 | In Stock |
|
| 10MG | 164 | In Stock |
|
| 25MG | 325 | In Stock |
|
| 50MG | 483 | In Stock |
|
| 100MG | 698 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSR59230A
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NoteResearch use only, not for human use.
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Brief DescriptionSR59230A is a potent, selective, and blood-brain barrier penetrating β3-adrenergic receptor antagonist with IC50s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively.
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DescriptionMDMA (20 mg/kg) produces a slowly developing hyperthermia, reaching a maximum increase of 1.8°C at 130 min post injection. SR59230A (0.5 mg/kg) produces a small but significant attenuation of the slowly developing hyperthermia to MDMA. SR59230A (5 mg/kg) reveals a significant and marked early hypothermic reaction to MDMA.
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Synonyms——
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PathwayAngiogenesis
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TargetAdrenergic Receptor
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number174689-39-5
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Formula Weight415.48
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Molecular FormulaC23H29NO6
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Purity>98% (HPLC)
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SolubilityDMSO : 31.25 mg/mL (75.21 mM; Need ultrasonic)
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SMILESO[C@@H](CN[C@H]1CCCC2=C1C=CC=C2)COC3=CC=CC=C3CC.O=C(O)C(O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Nisoli E, et al. Functional studies of the first selective beta 3-adrenergic receptor antagonist SR 59230A in rat brown adipocytes.Mol Pharmacol. 1996 Jan;49(1):7-14.
2. Kanzler SA, et al. Involvement of β3-adrenergic receptors in the control of food intake in rats.Braz J Med Biol Res. 2011 Nov;44(11):1141-7.
3. Bruno G, et al. β3-adrenoreceptor blockade reduces tumor growth and increases neuronal differentiation in neuroblastoma via SK2/S1P2 modulation.Oncogene. 2020 Jan;39(2):368-384.
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