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SR11237
CAS No. 146670-40-8
SR11237 ( BMS-649 )
Catalog No. M27716 CAS No. 146670-40-8
SR11237 is a Pan retinoid X receptor (RXR) agonist. SR11237 causes RXR/RXR homodimers to form and transactivate a reporter gene containing a RXR-response element.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 170 | Get Quote |
|
| 10MG | 258 | Get Quote |
|
| 25MG | 520 | Get Quote |
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| 50MG | 750 | Get Quote |
|
| 100MG | 1035 | Get Quote |
|
| 500MG | 2061 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameSR11237
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NoteResearch use only, not for human use.
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Brief DescriptionSR11237 is a Pan retinoid X receptor (RXR) agonist. SR11237 causes RXR/RXR homodimers to form and transactivate a reporter gene containing a RXR-response element.
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DescriptionSR11237 is a Pan retinoid X receptor (RXR) agonist. SR11237 causes RXR/RXR homodimers to form and transactivate a reporter gene containing a RXR-response element.(In Vitro):SR11237 is effective at transactivating a chloramphenicol acetyltransferase reporter gene through RXRs but not retinoic acid receptors in COS-1 cells.(In Vivo):In Sprague-Dawley rats, SR11237 (BMS-649) (25 mg/kg; i.p.) Caused disturbed ossification and bone morphology in rats, including premature growth plate closure and infiltration of ossified tissue through the central epiphysis.
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SynonymsBMS-649
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PathwayOthers
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TargetOther Targets
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RecptorAurora A
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Research Area——
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Indication——
Chemical Information
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CAS Number146670-40-8
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Formula Weight380.5
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Molecular FormulaC24H28O4
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1(C)CCC(C)(C)c2cc(ccc12)C1(OCCO1)c1ccc(cc1)C(O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Ando R, et al. 3-Cyano-6-(5-methyl-3-pyrazoloamino)pyridines: selective Aurora A kinase inhibitors. Bioorg Med Chem Lett. 2010;20(15):4709-4711.
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