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SR-4370

CAS No. 1816294-67-3

SR-4370( SR-4370 | SR 4370 | SR4370 )

Catalog No. M17385 CAS No. 1816294-67-3

SR-?4370 is an HDAC inhibitor. SR-?4370 exhibited IC50 values of 0.5 μM, 0.1 μM and 0.06 μM towards HDAC1, HDAC2 and HDAC3.

Purity : >98% (HPLC)

COA

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HNMR

HPLC

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Biological Information

Product Name

SR-4370
Note

Research use only, not for human use.
Brief Description

SR-?4370 is an HDAC inhibitor. SR-?4370 exhibited IC50 values of 0.5 μM, 0.1 μM and 0.06 μM towards HDAC1, HDAC2 and HDAC3.
Description

SR-?4370 is an HDAC inhibitor. SR-?4370 exhibited IC50 values of 0.5 μM, 0.1 μM and 0.06 μM towards HDAC1, HDAC2 and HDAC3, resp. SR-?4370 is reported in WO 2015153516.
In Vitro

SR-4370 is an inhibitor of HDAC, with IC50s of 0.13 μM, 0.58 μM, 0.006 μM, 2.3 μM, and 3.4 μM for HDAC1, HDAC2, HDAC3, HDAC8, and HDAC6, respectively. SR-4370 is cytotoxic to the breast cancer cells (MDA-MB-231), with an IC50 of 12.6 μM.
In Vivo

——
Synonyms

SR-4370 | SR 4370 | SR4370
Pathway

Cell Cycle/DNA Damage
Target

GPR
Recptor

HDAC1| HDAC2| HDAC3
Research Area

Cancer
Indication

——

Chemical Information

CAS Number

1816294-67-3
Formula Weight

304.34
Molecular Formula

C17H18F2N2O
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 150 mg/mL; 492.89 mM
SMILES

Fc1c(cccc1F)c2ccc(cc2)C(=O)NNCCCC
Chemical Name

N'-butyl-2',3'-difluoro-[1,1'-biphenyl]-4-carbohydrazide

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. D Liao, etal. HDAC Inhibitor Compounds and Methods of Treatment

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