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SR-18292
CAS No. 2095432-55-4
SR-18292 ( SR-18292; SR 18292; SR18292 )
Catalog No. M17428 CAS No. 2095432-55-4
SR-18292 is a PPAR gamma coactivator-1α (PGC-1α) inhibitor, which increases PGC-1α acetylation, suppresses gluconeogenic gene expression and reduces glucose production in hepatocytes.
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 31 | In Stock |
|
| 5MG | 50 | In Stock |
|
| 10MG | 80 | In Stock |
|
| 25MG | 170 | In Stock |
|
| 50MG | 267 | In Stock |
|
| 100MG | 425 | In Stock |
|
| 500MG | 888 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSR-18292
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NoteResearch use only, not for human use.
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Brief DescriptionSR-18292 is a PPAR gamma coactivator-1α (PGC-1α) inhibitor, which increases PGC-1α acetylation, suppresses gluconeogenic gene expression and reduces glucose production in hepatocytes.
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DescriptionSR-18292 is a PGC-1α inhibitor. SR-18292 reduces blood glucose, strongly increases hepatic insulin sensitivity, and improves glucose homeostasis in dietary and genetic mouse models of T2D.
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SynonymsSR-18292; SR 18292; SR18292
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PathwayCell Cycle/DNA Damage
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TargetHDAC
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RecptorPGC-1α
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Research AreaMetabolic Disease
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Indication——
Chemical Information
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CAS Number2095432-55-4
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Formula Weight366.51
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Molecular FormulaC23H30N2O2
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Purity98%
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SolubilityDMSO : ≥ 100 mg/mL; 272.85 mM
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SMILESCC(C)(C)N(Cc1ccc(C)cc1)CC(O)COc3cccc2nccc23
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Chemical Name1-((1H-indol-4-yl)oxy)-3-(tert-butyl(4-methylbenzyl)amino)propan-2-ol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Sharabi K,etal.Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes.Cell. 2017 Mar 23;169(1):148-160.
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SR-18292
SR-18292 is a PPAR gamma coactivator-1α (PGC-1α) inhibitor, which increases PGC-1α acetylation, suppresses gluconeogenic gene expression and reduces glucose production in hepatocytes.
