SR-18292 ( SR-18292; SR 18292; SR18292 )

Catalog No. M17428 CAS No. 2095432-55-4

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Product Name

SR-18292
Note

Research use only, not for human use.
Brief Description

SR-18292 is a PPAR gamma coactivator-1α (PGC-1α) inhibitor, which increases PGC-1α acetylation, suppresses gluconeogenic gene expression and reduces glucose production in hepatocytes.
Description

SR-18292 is a PGC-1α inhibitor. SR-18292 reduces blood glucose, strongly increases hepatic insulin sensitivity, and improves glucose homeostasis in dietary and genetic mouse models of T2D.
Synonyms

SR-18292; SR 18292; SR18292
Pathway

Cell Cycle/DNA Damage
Target

HDAC
Recptor

PGC-1α
Research Area

Metabolic Disease
Indication

——

CAS Number

2095432-55-4
Formula Weight

366.51
Molecular Formula

C23H30N2O2
Purity

98%
Solubility

DMSO : ≥ 100 mg/mL; 272.85 mM
SMILES

CC(C)(C)N(Cc1ccc(C)cc1)CC(O)COc3cccc2nccc23
Chemical Name

1-((1H-indol-4-yl)oxy)-3-(tert-butyl(4-methylbenzyl)amino)propan-2-ol

1.Sharabi K,etal.Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes.Cell. 2017 Mar 23;169(1):148-160.

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