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SPX-101

CAS No. 2219362-20-4

SPX-101( SPX101 | SPX 101 )

Catalog No. M13538 CAS No. 2219362-20-4

SPX-101 is a specific, peptide mimetic promoter of epithelial sodium channel (ENaC) internalization.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SPX-101
  • Note
    Research use only, not for human use.
  • Brief Description
    SPX-101 is a specific, peptide mimetic promoter of epithelial sodium channel (ENaC) internalization.
  • Description
    SPX-101 is a specific, peptide mimetic promoter of epithelial sodium channel (ENaC) internalization, binds selectively to ENaC and promotes internalization of the α-, β-, and γ-subunits; promotes durable reduction of ENaC membrane concentration, increases mucus transport in the β-ENaC mouse model as well as the sheep model of CF.Fibrosis Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    SPX101 | SPX 101
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Sodium Channel
  • Recptor
    Sodium Channel
  • Research Area
    Other Indications
  • Indication
    Fibrosis

Chemical Information

  • CAS Number
    2219362-20-4
  • Formula Weight
    1179.385
  • Molecular Formula
    C53H90N14O16
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    D-Ala-D-Ala-Leu-Pro-Ile-Pro-Leu-Asp-Gln-Thr-D-Ala-D-Ala-NH2

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Scott DW, et al. Am J Respir Crit Care Med. 2017 Sep 15;196(6):734-744. 2. Lennox A, et al. Am J Respir Crit Care Med. 2017 Sep 15;196(6):671-672.
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