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SPX-101
CAS No. 2219362-20-4
SPX-101( SPX101 | SPX 101 )
Catalog No. M13538 CAS No. 2219362-20-4
SPX-101 is a specific, peptide mimetic promoter of epithelial sodium channel (ENaC) internalization.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameSPX-101
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NoteResearch use only, not for human use.
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Brief DescriptionSPX-101 is a specific, peptide mimetic promoter of epithelial sodium channel (ENaC) internalization.
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DescriptionSPX-101 is a specific, peptide mimetic promoter of epithelial sodium channel (ENaC) internalization, binds selectively to ENaC and promotes internalization of the α-, β-, and γ-subunits; promotes durable reduction of ENaC membrane concentration, increases mucus transport in the β-ENaC mouse model as well as the sheep model of CF.Fibrosis Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsSPX101 | SPX 101
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PathwayMembrane Transporter/Ion Channel
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TargetSodium Channel
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RecptorSodium Channel
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Research AreaOther Indications
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IndicationFibrosis
Chemical Information
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CAS Number2219362-20-4
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Formula Weight1179.385
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Molecular FormulaC53H90N14O16
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical NameD-Ala-D-Ala-Leu-Pro-Ile-Pro-Leu-Asp-Gln-Thr-D-Ala-D-Ala-NH2
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Scott DW, et al. Am J Respir Crit Care Med. 2017 Sep 15;196(6):734-744.
2. Lennox A, et al. Am J Respir Crit Care Med. 2017 Sep 15;196(6):671-672.
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