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PF-05089771
CAS No. 1430806-04-4
PF-05089771 ( PF05089771 )
Catalog No. M11822 CAS No. 1430806-04-4
PF-05089771 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 11 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 104 | In Stock |
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| 10MG | 149 | In Stock |
|
| 25MG | 369 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NamePF-05089771
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NoteResearch use only, not for human use.
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Brief DescriptionPF-05089771 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 11 nM.
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DescriptionPF-05089771 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 11 nM, >1,000-fold selectivity over Nav1.3, 1.4 and Nav1.5, 1.8; interacts with the voltage-sensor domain (VSD) of domain IV, blocks all Nav1.7 splice variants with similar potency (5N11L, 5A11S, 5A11L and 5N11S, IC50s=11=33 nM); displays high selectivity over L-type calcium channels, KvLQT and hERG potassium channels; demonstrates in vivo efficacy in a mouse capsaicin-induced neurogenic flare model.
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SynonymsPF05089771
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PathwayMembrane Transporter/Ion Channel
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TargetSodium Channel
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RecptorNa(V1.7) channel
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Research AreaNeurological Disease
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IndicationPain
Chemical Information
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CAS Number1430806-04-4
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Formula Weight500.34
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Molecular FormulaC18H12Cl2FN5O3S2
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1=CC=C(C=C1)S(=O)(=O)O.C1=CC(=C(C=C1Cl)C2=C(NN=C2)N)OC3=CC(=C(C=C3Cl)S(=O)(=O)NC4=CSC=N4)F
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Chemical Name4-[2-(5-amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-(1,3-thiazol-4-yl)benzenesulfonamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Swain NA, et al. J Med Chem. 2017 Aug 24;60(16):7029-7042.
2. Theile JW, et al. Mol Pharmacol. 2016 Nov;90(5):540-548.
3. Alexandrou AJ, et al. PLoS One. 2016 Apr 6;11(4):e0152405.
4. Chernov-Rogan T, et al. Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E792-E801.
2. Theile JW, et al. Mol Pharmacol. 2016 Nov;90(5):540-548.
3. Alexandrou AJ, et al. PLoS One. 2016 Apr 6;11(4):e0152405.
4. Chernov-Rogan T, et al. Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E792-E801.
molnova catalog
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