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Home - Products - Proteasome/Ubiquitin - p97 - SPP-86

SPP-86

CAS No. 1357349-91-7

SPP-86( —— )

Catalog No. M26823 CAS No. 1357349-91-7

SPP-86 is an effective and selective cell-permeable inhibitor of RET tyrosine kinase with an IC50 of 8 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SPP-86
  • Note
    Research use only, not for human use.
  • Brief Description
    SPP-86 is an effective and selective cell-permeable inhibitor of RET tyrosine kinase with an IC50 of 8 nM.
  • Description
    SPP-86 is an effective and selective cell-permeable inhibitor of RET tyrosine kinase with an IC50 of 8 nM.(In Vitro):Administration of SPP-86 (0-10 μM) suppresses RET-induced phosphatidylinositide 3-kinases (PI3K)/Akt and MAPK signaling and estrogen receptorα (ERα) phosphorylation in MCF7 cells. Administration of SPP-86 (0-10 μM) also supppresses MAPK signaling and proliferation in RET/PTC1 expressing TPC1 compared to 8505C or C643 cells .
  • In Vitro
    SPP86 (0-10 μM) inhibits MAPK signaling and proliferation in RET/PTC1 expressing TPC1 but not 8505C or C643 cells.SPP86 (0-10 μM) inhibits RET- induced phosphatidylinositide 3-kinases (PI3K)/Akt and MAPK signaling and estrogen receptorα (ERα) phosphorylation in MCF7 cells. Western Blot AnalysisCell Line:Thyroid cancer derived cell lines expressing the RET/PTC1 rearrangement (TPC1), BRAFV600E (8505C) or RASG13R (C643) mutations.Concentration:0-10 μM.Incubation Time:90 min.Result:Inhibited RET- induced ERK1/2 phosphorylation in thyroid cancer cell lines.Western Blot AnalysisCell Line:MCF7 cells (human breast cancer).Concentration:0-10 μM.Incubation Time:30 min.Result:Inhibited RET- induced ERα phosphorylation and proliferation in MCF7 cells.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Proteasome/Ubiquitin
  • Target
    p97
  • Recptor
    α-MSH
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1357349-91-7
  • Formula Weight
    277.331
  • Molecular Formula
    C16H15N5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (360.59 mM)
  • SMILES
    CC(C)n1nc(C#Cc2ccccc2)c2c(N)ncnc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Katoulis A, et al. A double-blind vehicle-controlled study of a preparation containing undecylenoyl phenylalanine 2% in the treatment of melasma in females. J Cosmet Dermatol. 2014 Jun;13(2):86-90.
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