SNS-032

CAS No. 345627-80-7

SNS-032 ( BMS-387032 )

Catalog No. M14183 CAS No. 345627-80-7

SNS-032 (BMS-387032)is a potent and selective inhibitor of CDK 2/7/9 with IC50 of 48 nM/62 nM/4 nM, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 39 In Stock
10MG 55 In Stock
25MG 79 In Stock
50MG 120 In Stock
100MG 203 In Stock
200MG 300 In Stock
500MG 503 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    SNS-032
  • Note
    Research use only, not for human use.
  • Brief Description
    SNS-032 (BMS-387032)is a potent and selective inhibitor of CDK 2/7/9 with IC50 of 48 nM/62 nM/4 nM, respectively.
  • Description
    SNS-032 (BMS-387032)is a potent and selective inhibitor of CDK 2/7/9 with IC50 of 48 nM/62 nM/4 nM, respectively; displays 10- and 20-fold selective over CDK1/cycB and CDK4/cycD (IC50=480 and 925 nM) respectively, and a panel of unrelated kinases, respectively; blocks the cell cycle via inhibition of CDKs 2 and 7, and transcription via inhibition of CDKs 7 and 9, has an A2780 cellular cytotoxicity assay IC50 of 95 nM; exhibits a efficacy profile in A2780 human ovarian carcinoma xenograft model.Blood Cancer,Phase 2 Discontinued
  • Synonyms
    BMS-387032
  • Pathway
    Angiogenesis
  • Target
    CDK
  • Recptor
    CDK2/CyclinA;CDK2/CyclinE;CDK7/CyclinH;CDK9/CyclinT;GSK-3α
  • Research Area
    Cancer
  • Indication
    Blood cancer

Chemical Information

  • CAS Number
    345627-80-7
  • Formula Weight
    380.53
  • Molecular Formula
    C17H24N4O2S2
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CC(C)(C)C1=CN=C(CSC2=CN=C(NC(=O)C3CCNCC3)S2)O1 |t:4,6,10,12|
  • Chemical Name
    4-Piperidinecarboxamide, N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Misra RN, et al. J Med Chem. 2004 Mar 25;47(7):1719-28.
2. Mukhopadhyay P, et al. Cancer Res. 2006 Feb 1;66(3):1758-66.
3. Chen R, et al. Blood. 2009 May 7;113(19):4637-45.
4. Heath EI, et al. Invest New Drugs. 2008 Feb;26(1):59-65.
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