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SNS-032
CAS No. 345627-80-7
SNS-032 ( BMS-387032 )
Catalog No. M14183 CAS No. 345627-80-7
SNS-032 (BMS-387032)is a potent and selective inhibitor of CDK 2/7/9 with IC50 of 48 nM/62 nM/4 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 39 | In Stock |
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| 10MG | 55 | In Stock |
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| 25MG | 79 | In Stock |
|
| 50MG | 120 | In Stock |
|
| 100MG | 203 | In Stock |
|
| 200MG | 300 | In Stock |
|
| 500MG | 503 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSNS-032
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NoteResearch use only, not for human use.
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Brief DescriptionSNS-032 (BMS-387032)is a potent and selective inhibitor of CDK 2/7/9 with IC50 of 48 nM/62 nM/4 nM, respectively.
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DescriptionSNS-032 (BMS-387032)is a potent and selective inhibitor of CDK 2/7/9 with IC50 of 48 nM/62 nM/4 nM, respectively; displays 10- and 20-fold selective over CDK1/cycB and CDK4/cycD (IC50=480 and 925 nM) respectively, and a panel of unrelated kinases, respectively; blocks the cell cycle via inhibition of CDKs 2 and 7, and transcription via inhibition of CDKs 7 and 9, has an A2780 cellular cytotoxicity assay IC50 of 95 nM; exhibits a efficacy profile in A2780 human ovarian carcinoma xenograft model.Blood Cancer,Phase 2 Discontinued
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SynonymsBMS-387032
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK2/CyclinA;CDK2/CyclinE;CDK7/CyclinH;CDK9/CyclinT;GSK-3α
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number345627-80-7
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Formula Weight380.53
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Molecular FormulaC17H24N4O2S2
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCC(C)(C)C1=CN=C(CSC2=CN=C(NC(=O)C3CCNCC3)S2)O1 |t:4,6,10,12|
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Chemical Name4-Piperidinecarboxamide, N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Misra RN, et al. J Med Chem. 2004 Mar 25;47(7):1719-28.
2. Mukhopadhyay P, et al. Cancer Res. 2006 Feb 1;66(3):1758-66.
3. Chen R, et al. Blood. 2009 May 7;113(19):4637-45.
4. Heath EI, et al. Invest New Drugs. 2008 Feb;26(1):59-65.
2. Mukhopadhyay P, et al. Cancer Res. 2006 Feb 1;66(3):1758-66.
3. Chen R, et al. Blood. 2009 May 7;113(19):4637-45.
4. Heath EI, et al. Invest New Drugs. 2008 Feb;26(1):59-65.
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