SNIPER(ER)-110 ( —— )

Catalog No. M16952 CAS No.

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

SNIPER(ER)-110
Note

Research use only, not for human use.
Brief Description

SNIPER(ER)-110 is a nongenetic IAP-dependent protein eraser (SNIPER) targeting estrogen receptor α (ERα), induces ERα degradation and induces apoptosis in MCF-7 human breast cancer cells.
Description

SNIPER(ER)-110 is a nongenetic IAP-dependent protein eraser (SNIPER) targeting estrogen receptor α (ERα), induces ERα degradation and induces apoptosis in MCF-7 human breast cancer cells; inhibits the growth of MCF-7 tumor xenografts in mice more potently than the previously characterized SNIPER(ER)-87, preferentially recruits XIAP, rather than cIAP1, to degrade ERα.
Synonyms

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Pathway

PROTACs
Target

PROTAC
Recptor

PROTAC
Research Area

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Indication

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CAS Number

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Formula Weight

1122.41
Molecular Formula

C66H83N5O11
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

(2S,4S)-1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-4-(3-((1-(4-((Z)-1-(4-hydroxyphenyl)-2-phenylbut-1-en-1-yl)phenoxy)-3-methyl-4-oxo-6,9,12-trioxa-3-azatetradecan-14-yl)oxy)phenoxy)-N-((R)-1,2,3,4-tetrahydronaphthalen-1-yl)pyrrolidine-2-carboxamide

1. Ohoka N, et al. J Biol Chem. 2018 May 4;293(18):6776-6790.

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