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5-(Biotinamido)pentylamine
CAS No. 115416-38-1
5-(Biotinamido)pentylamine( —— )
Catalog No. M35048 CAS No. 115416-38-1
5-(Biotinamido)pentylamine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 41 | In Stock |
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| 10MG | 60 | In Stock |
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| 25MG | 93 | In Stock |
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| 50MG | 147 | In Stock |
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| 100MG | 230 | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product Name5-(Biotinamido)pentylamine
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NoteResearch use only, not for human use.
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Brief Description5-(Biotinamido)pentylamine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
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Description5-Biotinamidopentylamine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
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In VitroPROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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In Vivo——
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Synonyms——
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PathwayPROTACs
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TargetPROTAC
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RecptorPROTAC Linker
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Research Area——
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Indication——
Chemical Information
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CAS Number115416-38-1
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Formula Weight328.47
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Molecular FormulaC15H28N4O2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (304.44 mM; Ultrasonic )
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SMILESC(CCCC(NCCCCCN)=O)[C@H]1[C@@]2([C@](CS1)(NC(=O)N2)[H])[H]
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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MS4078
MS4078 is a novel PROTAC (degrader) of ALK, potently decreases cellular levels of oncogenic active ALK fusion proteins in a concentration- and time-dependent manner in SU-DHL-1 lymphoma and NCI-H2228 lung cancer cells (DC50=11 nM).
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HDAC6 degrader 9c
HDAC6 degrader 9c (dHDAC6 9c) is a bifunctional molecule (dHDAC6) that could selectively degrade HDAC6, by conjugating non-selective HDAC inhibitor to a thalidomide-type E3 ligase ligand.
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DBCO-S-S-PEG3-biotin
DBCO-S-S-PEG3-biotin is a cleavable reagent for introduction of a biotin moiety to azide-containing biomolecules using copper-free Click Chemistry.?The disulfide bond in this linker can be cleaved using reducing agents such as DTT, BME and TCEP to remove the biotin label.?PEG Linkers can be used in the synthesis of PROTACs.
