SNIPER(AR)-51
CAS No. 2113688-43-8
SNIPER(AR)-51 ( SNIPER AR-51 )
Catalog No. M13362 CAS No. 2113688-43-8
SNIPER(AR)-51 is a specific and nongenetic, protein degradation inducer of androgen receptor, consistiong of AR ligand and IAP ligand and linker; induces proteasomal degradation of AR and shows effective protein knockdown activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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100MG | Get Quote | Get Quote |
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200MG | Get Quote | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameSNIPER(AR)-51
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NoteResearch use only, not for human use.
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Brief DescriptionSNIPER(AR)-51 is a specific and nongenetic, protein degradation inducer of androgen receptor, consistiong of AR ligand and IAP ligand and linker; induces proteasomal degradation of AR and shows effective protein knockdown activity.
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DescriptionSNIPER(AR)-51 is a specific and nongenetic, protein degradation inducer of androgen receptor, consistiong of AR ligand and IAP ligand and linker; induces proteasomal degradation of AR and shows effective protein knockdown activity; inhibits AR-mediated gene expression and proliferation of androgen-dependent prostate cancer cells, and efficiently induces caspase activation and apoptosis in prostate cancer cells.
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SynonymsSNIPER AR-51
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PathwayPROTACs
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TargetPROTAC
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RecptorPROTAC
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number2113688-43-8
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Formula Weight984.23
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Molecular FormulaC55H65N7O8S
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Purity>98% (HPLC)
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Solubility——
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SMILESC[C@H](NC)C(N[C@@H](C1CCCCC1)C(N2[C@H](C3=NC(C(C4=CC=CC(OCCOCCOCCOCCOC5=CC=C(CN6C(C)=C(C#N)C(C7=CC=C(C#N)C=C7)=C6C)C=C5)=C4)=O)=CS3)CCC2)=O)=O
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Chemical Name(S)-N-((S)-2-((S)-2-(4-(3-(2-(2-(2-(2-(4-((3-cyano-4-(4-cyanophenyl)-2,5-dimethyl-1H-pyrrol-1-yl)methyl)phenoxy)ethoxy)ethoxy)ethoxy)ethoxy)benzoyl)thiazol-2-yl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)-2-(methylamino)propanamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Shibata N, et al. J Med Chem. 2017 Jun 23. doi: 10.1021/acs.jmedchem.7b00168.
molnova catalog
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