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dBRD9

CAS No. 2170679-45-3

dBRD9( dBRD 9 )

Catalog No. M13465 CAS No. 2170679-45-3

dBRD9 is a PROTAC that bridge the BRD9 bromodomain and the cereblon E3 ubiquitin ligase complex.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 434 In Stock
5MG 312 In Stock
10MG 502 In Stock
25MG 874 In Stock
50MG 1293 In Stock
100MG 1795 In Stock
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Biological Information

  • Product Name
    dBRD9
  • Note
    Research use only, not for human use.
  • Brief Description
    dBRD9 is a PROTAC that bridge the BRD9 bromodomain and the cereblon E3 ubiquitin ligase complex.
  • Description
    dBRD9 is a PROTAC that bridge the BRD9 bromodomain and the cereblon E3 ubiquitin ligase complex; exhibits markedly enhanced potency compared to parental ligands (10-100 fold).
  • In Vitro
    Western Blot Analysis Cell Line:MOLM-13 cells.Concentration:0.5, 5, 50, 500 and 5000 nM.Incubation Time:4 h.Result:Reduced the expression of BRD9.
  • In Vivo
    ——
  • Synonyms
    dBRD 9
  • Pathway
    PROTACs
  • Target
    PROTAC
  • Recptor
    PROTAC
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2170679-45-3
  • Formula Weight
    783.839
  • Molecular Formula
    C40H45N7O10
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (127.58 mM)
  • SMILES
    O=C(NCCOCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CN(CC4=C(OC)C=C(C(C5=CC=NC=C65)=CN(C)C6=O)C=C4OC)C
  • Chemical Name
    2-((2,6-dimethoxy-4-(2-methyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)benzyl)(methyl)amino)-N-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethyl)acetamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Remillard D, et al. Angew Chem Int Ed Engl. 2017 May 15;56(21):5738-5743.
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