SNIPER(ABL)-062 ( SNIPER ABL 062 )

Catalog No. M13419 CAS No. 2140260-89-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

SNIPER(ABL)-062
Note

Research use only, not for human use.
Brief Description

SNIPER(ABL)-062 is a novel, potent SNIPER molecule that tethers BCR-ABL inhibitor to a ligand of IAP, causes potent BCR-ABL degradation.
Description

SNIPER(ABL)-062 is a novel, potent SNIPER molecule that tethers BCR-ABL inhibitor to a ligand of IAP, causes potent BCR-ABL degradation; shows desirable binding affinities against ABL1, cIAP1/2, and XIAP (IC50=80-500 nM), inhibits BCR-ABL-mediated signaling pathways and CML proliferation in cells expressing BCR-ABL.
Synonyms

SNIPER ABL 062
Pathway

PROTACs
Target

PROTAC
Recptor

PROTAC
Research Area

——
Indication

——

CAS Number

2140260-89-3
Formula Weight

1089.66
Molecular Formula

C53H63ClF2N10O9S
Purity

>98% (HPLC)
Solubility

——
SMILES

CC(C(=O)NC(C1CCCCC1)C(=O)N2CCCC2C3=NC(=CS3)C(=O)C4=CC(=CC=C4)OCCOCCOCCNC(=O)C5CCN(C5)C6=C(C=C(C=N6)C(=O)NC7=CC=C(C=C7)OC(F)(F)Cl)C8=CC=NN8)NC
Chemical Name

N-(4-(chlorodifluoromethoxy)phenyl)-6-(3-((2-(2-(2-(3-(2-((S)-1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidin-2-yl)thiazole-4-carbonyl)phenoxy)ethoxy)ethoxy)ethyl)carbamoyl)pyrrolidin-1-yl)-5-(1H-pyrazol-5-yl)nicotinamide

1. Shimokawa K, et al. ACS Med Chem Lett. 2017 Sep 14;8(10):1042-1047.

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