SN-32976 ( SN 32976;SN32976 )

Catalog No. M10996 CAS No. 1246202-11-8

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Product Name

SN-32976
Note

Research use only, not for human use.
Brief Description

SN-32976 is a novel, potent and selective class I PI3K and mTOR inhibitor.
Description

SN-32976 is a novel, potent and selective class I PI3K and mTOR inhibitor with IC50 of 15.1/461/110/134/194 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ/mTOR, respectively; displays preferential activity for PI3Kα and spares PI3Kδ relative to the other inhibitors, and shows less off-target activity in a panel of 442 kinases; inhibits pAKT expression and cell proliferation at nM concentration, induces a greater extent and duration of pAKT inhibition in tumors than pictilisib, dactolisib and omipalisib in animal models.
Synonyms

SN 32976;SN32976
Pathway

PI3K/Akt/mTOR signaling
Target

PI3K
Recptor

PI3K
Research Area

Cancer
Indication

——

CAS Number

1246202-11-8
Formula Weight

581.64
Molecular Formula

C24H33F2N9O4S
Purity

>98% (HPLC)
Solubility

——
SMILES

CN(C)CCS(=O)(=O)N1CCN(CC1)C2=NC(=NC(=N2)N3C4=C(C(=CC=C4)OC)N=C3C(F)F)N5CCOCC5
Chemical Name

2-((4-(4-(2-(difluoromethyl)-4-methoxy-1H-benzo[d]imidazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)piperazin-1-yl)sulfonyl)-N,N-dimethylethan-1-amine

1. Rewcastle GW, et al. Oncotarget. 2017 May 9. doi: 10.18632/oncotarget.17730.

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