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SAR405
CAS No. 1523406-39-4
SAR405 ( SAR-405;SAR 405 )
Catalog No. M12127 CAS No. 1523406-39-4
SAR405 is a highly potent and selective PI3K class III isoform Vps34 inhibitor with IC50 of 1.2 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 65 | Get Quote |
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| 5MG | 95 | Get Quote |
|
| 10MG | 170 | Get Quote |
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| 25MG | 340 | Get Quote |
|
| 50MG | 521 | Get Quote |
|
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameSAR405
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NoteResearch use only, not for human use.
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Brief DescriptionSAR405 is a highly potent and selective PI3K class III isoform Vps34 inhibitor with IC50 of 1.2 nM.
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DescriptionSAR405 is a highly potent and selective PI3K class III isoform Vps34 inhibitor with IC50 of 1.2 nM, inhibits the formation of autophagosomes in GFP-LC3 cells with IC50 of 4 nM; displays no activity against class I and II PI3K isoforms (IC50>10 uM), as well as PIKKs, ATM, ATR and DNA-PK, SMG1; affects both late endosome-lysosome compartments and prevents autophagy, shows synergistic antiproliferative activity in renal tumor cell lines combined with mTOR inhibitor everolimus; enhances the antitumor efficacy of cisplatin in mouse xenograft model of HNSCC.
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SynonymsSAR-405;SAR 405
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorPI3K
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1523406-39-4
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Formula Weight443.85
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Molecular FormulaC19H21ClF3N5O2
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 27 mg/mL
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SMILESO=C1C=C(N2[C@H](C)COCC2)N=C3N(CC4=CC(Cl)=CN=C4)[C@H](C(F)(F)F)CCN31
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Chemical Name4H-Pyrimido[1,2-a]pyrimidin-4-one, 9-[(5-chloro-3-pyridinyl)methyl]-6,7,8,9-tetrahydro-2-[(3R)-3-methyl-4-morpholinyl]-8-(trifluoromethyl)-, (8S)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ronan B, et al. Nat Chem Biol. 2014 Dec;10(12):1013-9.
2. Pasquier B. Autophagy. 2015 Apr 3;11(4):725-6.
3. Valet C, et al. Blood. 2017 Nov 2;130(18):2032-2042.
4. New J, et al. Cancer Res. 2017 Dec 1;77(23):6679-6691.
2. Pasquier B. Autophagy. 2015 Apr 3;11(4):725-6.
3. Valet C, et al. Blood. 2017 Nov 2;130(18):2032-2042.
4. New J, et al. Cancer Res. 2017 Dec 1;77(23):6679-6691.
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