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SMS1-IN-1

CAS No. 1807943-38-9

SMS1-IN-1( —— )

Catalog No. M26452 CAS No. 1807943-38-9

SMS1-IN-1 is a potent inhibitor of sphingomyelin synthase 1 (SMS1, IC50 = 2.1 μM), and can be used in the atherosclerosis studies.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SMS1-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    SMS1-IN-1 is a potent inhibitor of sphingomyelin synthase 1 (SMS1, IC50 = 2.1 μM), and can be used in the atherosclerosis studies.
  • Description
    SMS1-IN-1 is a potent inhibitor of sphingomyelin synthase 1 (SMS1, IC50 = 2.1 μM), and can be used in the atherosclerosis studies. (In Vitro):SMS1-IN-1 (2.5, 10 and 50?μM) shows inhibitory effect against SMS1 in a dose-dependent manner.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    D2 receptor| D3 receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1807943-38-9
  • Formula Weight
    503.41
  • Molecular Formula
    C23H23BrN2O4S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (496.61 mM)
  • SMILES
    Brc1ccc(CNC(=O)COc2ccc(cc2)S(=O)(=O)NCCc2ccccc2)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Holmes et al (2010) The identification of a selective DA D2 partial agonist, D3 antagonist displaying high levels of brain exposure. Bioorg.Med.Chem.Lett. 20 2013
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