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NLS-StAx-h

CAS No.

NLS-StAx-h ( )

Catalog No. M30614 CAS No.

Wnt inhibitor (IC50 = 1.4 μM). Stapled peptide inhibitor of oncogenic Wnt signaling. Inhibits β-catenin-transcription factor interactions. Inhibits proliferation and migration of colorectal cancer cells. Cell permeable.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    NLS-StAx-h
  • Note
    Research use only, not for human use.
  • Brief Description
    Wnt inhibitor (IC50 = 1.4 μM). Stapled peptide inhibitor of oncogenic Wnt signaling. Inhibits β-catenin-transcription factor interactions. Inhibits proliferation and migration of colorectal cancer cells. Cell permeable.
  • Description
    Wnt inhibitor (IC50 = 1.4 μM). Stapled peptide inhibitor of oncogenic Wnt signaling. Inhibits β-catenin-transcription factor interactions. Inhibits proliferation and migration of colorectal cancer cells. Cell permeable.
  • Synonyms
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    --
  • Formula Weight
    3445.3
  • Molecular Formula
    C161H275N55O29
  • Purity
    >98% (HPLC)
  • Solubility
    water:1 mg/mL
  • SMILES
    O=C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(NCCOCCOCC(N[C@@H](CCCCNC(N)=N)C(N[C@@H](CCCCNC(N)=N)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N3[C@@H](CCC3)C(N[C@@H](CCCCNC(N)=N)C(N[C@@](C)(CCC/C=C\CCC[C@@](C(N[C@H](CC4=CNC=N4)C(N[C@H](C(C)C)C(N[C@H](CCCCNC(N)=N)C(N[C@H](CCCCNC(N)=N)C(N[C@H](C(C)C)C(N[C@H](CC5=CNC6=CC=CC=C56)C(N[C@H](CCCCNC(N)=N)C(N)=O)=O)=O)=O)=O)=O)=O)=O)(C)N7)C(N[C@@H]([C@@H](C)CC)C(N[C@H](CC(C)C)C(N[C@H](CC(O)=O)C7=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]8NCCC8
  • Chemical Name

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Dietrich et al (2017) Cell permeable stapled peptide inhibitor of Wnt signaling that targets beta -catenin protein-protein Interactions. Cell Chem.Biol. 24 958 PMID:
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