SMER3

Research use only, not for human use.

SMER 3 is an inhibitor of the Skp1-Cullin-F-box (SCF)(Met30) ubiquitin ligase, a member of the SCF E3-ligase family, which regulates diverse cellular processes including transcription, cell-cycle control and immune response.

SMER 3 is an inhibitor of the Skp1-Cullin-F-box (SCF)(Met30) ubiquitin ligase, a member of the SCF E3-ligase family, which regulates diverse cellular processes including transcription, cell-cycle control and immune response.(In Vitro):SMER 3 and rapidly increased PFKFB3 protein levels. Accordingly, ubiquitin-bound PFKFB3 was lower in E2- or G1-treated HUVECs. Both agents increased deubiquitinase USP19 levels through GPER signaling.(In Vivo):SMER 3 diminishes binding of the F-box subunit Met30 to the SCF core complex in vivo and show evidence for SMER 3 directly binding to Met30.

SMER 3; SMER3

Others

Other Targets

mGluR5

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67200-34-4

224.2

C11H4N4O2

>98% (HPLC)

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O=C1C2=CC=CC=C2C3=NC4=NON=C4N=C31

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(-20℃)

With Ice Pack

≥ 2 years