SLLN-15
CAS No.
SLLN-15 ( Autophagy inducer SLLN-15 )
Catalog No. M16931 CAS No.
SLLN-15 (Autophagy inducer SLLN-15) is a potent, orally available inducer of autophagy that selectively activated cytostatic macroautophagy/autophagy in TNBC preclinical models.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameSLLN-15
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NoteResearch use only, not for human use.
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Brief DescriptionSLLN-15 (Autophagy inducer SLLN-15) is a potent, orally available inducer of autophagy that selectively activated cytostatic macroautophagy/autophagy in TNBC preclinical models.
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DescriptionSLLN-15 (Autophagy inducer SLLN-15) is a potent, orally available inducer of autophagy that selectively activated cytostatic macroautophagy/autophagy in TNBC preclinical models, promotes AURKA degradation and ; induced a dose-dependent anti-proliferative activity in the TNBC cell lines MDA-MB-231 and BT-20 via induction of autophagy and autophagic flux, associated with a selective inhibition of AKT-MTOR signaling; SLLN-15-induced autophagy in TNBC cells was also associated with decreased AURKA expression decreased AKT phosphorylation and subsequent blockage of the AKT-MTOR pathway; demonstrates anticancer and anti-metastatic activity in mice bearing TNBC.
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SynonymsAutophagy inducer SLLN-15
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PathwayAutophagy
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TargetAutophagy
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RecptorAutophagy
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Research Area——
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Indication——
Chemical Information
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CAS Number--
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Formula Weight507.36
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Molecular FormulaC19H23N7Se2
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Purity>98% (HPLC)
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Solubility——
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SMILESC12=NC(NC3=CC=C(N4CC[Se]CC4)C=C3)=NC(N[C@@H]5C[Se]CC5)=C1N=CN2
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Chemical Name(S)-N2-(4-selenomorpholinophenyl)-N6-(tetrahydroselenophen-3-yl)-9H-purine-2,6-diamine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chang CH, et al. Autophagy. 2019 Feb 17. doi: 10.1080/15548627.2019.1582951.
molnova catalog
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