SM13

Research use only, not for human use.

SM13 is a novel small molecule that blocks p53-MDM2 interaction and induces apoptosis both in vitro and in vivo.

SM13 is a novel small molecule that blocks p53-MDM2 interaction and induces apoptosis both in vitro and in vivo; reduces cell proliferation and induces apoptosis in vitro in cells carrying either p53 WT or mutated gene, suggesting that its effect is independent from p53 transcriptional activity; induces cancer cell death in a dose-dependent manner through the activation of the mitochondrial-dependent death signalling in p53-mutated cells; reduces tumour growth in vivo.

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SM 13

Apoptosis

MDM2-p53

MDM2-p53

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1445992-93-7

481.405

C21H25BrN2O4S

>98% (HPLC)

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5-bromo-3'-(cyclohexane carbonyl)-1-methyl-2-oxospiro[indoline-3,2'-thiazolidine

(-20℃)

With Ice Pack

≥ 2 years