SLMP53‐1

Research use only, not for human use.

A novel reactivator of wild-type and mutant p53, shows a p53-dependent anti-proliferative activity in human wt and mut p53R280K-expressing tumor cells.

A novel reactivator of wild-type and mutant p53, shows a p53-dependent anti-proliferative activity in human wt and mut p53R280K-expressing tumor cells; enhances p53 transcriptional activity and restores wt-like DNA binding ability to mut p53R280K; inhibits the growth of wt/mut p53-expressing tumors in xenograft mice models, without apparent toxicity.

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Apoptosis

MDM2-p53

MDM2-p53

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1643469-17-3

318.376

C20H18N2O2

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (785.25 mM)

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(3S,9bR)-3-((1H-indol-3-yl)methyl)-9b-methyl-2,3-dihydrooxazolo[2,3-a]isoindol-5(9bH)-one

(-20℃)

With Ice Pack

≥ 2 years