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SKLB1002
CAS No. 1225451-84-2
SKLB1002 ( SKLB1002; SKLB 1002; SKLB1002 )
Catalog No. M17891 CAS No. 1225451-84-2
SKLB1002 is a potent and ATP-competitive VEGFR2 inhibitor with IC50 of 32 nM.
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 45 | In Stock |
|
| 5MG | 64 | In Stock |
|
| 10MG | 86 | In Stock |
|
| 25MG | 194 | In Stock |
|
| 50MG | 324 | In Stock |
|
| 100MG | 527 | In Stock |
|
| 500MG | 1143 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSKLB1002
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NoteResearch use only, not for human use.
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Brief DescriptionSKLB1002 is a potent and ATP-competitive VEGFR2 inhibitor with IC50 of 32 nM.
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DescriptionSKLB1002 is a new potent VEGFR2 inhibitor, which could significantly inhibit HUVEC proliferation, migration, invasion, and tube formation. Western blot analysis was conducted, which indicated that SKLB1002 inhibited VEGF-induced phosphorylation of VEGFR2 kinase and the downstream protein kinases including extracellular signal-regulated kinase, focal adhesion kinase, and Src. In vivo zebrafish model experiments showed that SKLB1002 remarkably blocked the formation of intersegmental vessels in zebrafish embryos. SKLB1002 inhibits angiogenesis and may be a potential drug candidate in anticancer therapy.
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SynonymsSKLB1002; SKLB 1002; SKLB1002
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PathwayOthers
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TargetOther Targets
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RecptorVEGFR2
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1225451-84-2
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Formula Weight320.39
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Molecular FormulaC13H12N4O2S2
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Purity98%
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SolubilityDMSO : 5.625 mg/mL 17.56 mM;
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SMILESCOc1c(OC)cc2c(Sc3nnc(C)s3)ncnc2c1
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Chemical Name2-((6,7-dimethoxyquinazolin-4-yl)thio)-5-methyl-1,3,4-thiadiazole
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zhang S, et al. Clin Y Res. 2011, 17(13), 4439-4450.
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